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首页> 外文期刊>Dermatologic surgery >Randomized comparison of Mohs micrographic surgery and surgical excision for small nodular basal cell carcinoma: tissue-sparing outcome.
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Randomized comparison of Mohs micrographic surgery and surgical excision for small nodular basal cell carcinoma: tissue-sparing outcome.

机译：Mohs显微外科手术和小结节性基底细胞癌手术切除的随机比较：保留组织的结果。

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BACKGROUND: Mohs micrographic surgery (MMS) is recognized globally as the criterion standard for high-risk basal cell carcinoma (BCC). The main advantage of MMS over conventional surgery is the chance of complete tumor removal, but it is also thought, based on experience, to be tissue sparing. OBJECTIVE: To determine whether MMS leaves smaller surgical defects than standard surgery. METHODS AND MATERIALS: This was a randomized trial involving 30 patients with a clinical diagnosis of BCC. Patients were randomly assigned to MMS or standard surgery. In the standard surgery group the BCCs were excised with 4-mm margins. In the MMS group, tumors were excised with 2-mm margins and subsequent stages of MMS until the tumor was completely removed. An observer unaware of the treatment allocation calculated the defect size. The main outcome measure was defect size in mm(2). RESULTS: The median area of the surgical defects in the MMS group was 116.6 mm(2), versus 187.7 mm(2) in the standard surgery group (95% confidence interval for difference=61-126, p<.001). CONCLUSIONS: This is the first randomized trial demonstrating that MMS is a tissue-sparing treatment. Trial registration: http://www.clinicaltrials.gov Identifier: NCT00571363. The authors have indicated no significant interest with commercial supporters.
机译：背景：莫氏显微外科手术（MMS）已被全球公认为高危基底细胞癌（BCC）的标准。与常规手术相比，MMS的主要优势在于可以完全切除肿瘤，但根据经验，它也被认为是节省了组织。目的：确定MMS是否比标准手术留下较小的手术缺陷。方法和材料：这是一项涉及30例临床诊断为BCC的患者的随机试验。患者被随机分配到MMS或标准手术中。在标准手术组中，BCC切缘为4 mm。在MMS组中，以2 mm的切缘切开肿瘤，然后切除MMS的各个阶段，直到肿瘤被完全清除。观察者不知道治疗的分配，计算出了缺陷的大小。主要结果指标是缺陷尺寸，单位为mm（2）。结果：MMS组的手术缺损中位面积为116.6 mm（2），而标准手术组为187.7 mm（2）（95％置信区间差异为61-126，p <.001）。结论：这是第一个随机试验，证明MMS是一种节省组织的治疗方法。试用注册：http://www.clinicaltrials.gov标识符：NCT00571363。作者表示对商业支持者没有太大兴趣。

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