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Advanced treatment modalities for vitiligo

机译：白癜风的先进治疗方式

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摘要

Background Vitiligo is an acquired multifocal and polygenic dyschromia that affects 1% to 3% of the world and presents as multiple depigmented macules and patches. Traditionally, the treatment of vitiligo has focused on pharmacologic interventions, but nearly half of all treated patients fail to respond successfully. Objective Several advanced techniques exist that can aid dermatologists in treating vitiligo in patients who do not respond favorably to traditional pharmacologic treatments. These advanced interventions include the use of the 308-nm excimer laser, total body depigmentation therapy with monobenzyl ether of hydroquinone, microdermabrasion, micropigmentation, khellin-UVA therapy, and surgical management using miniature punch grafting, suction blister grafting, and epidermal cultures. Materials and Methods This article reviews the current literature on these advanced treatment modalities for vitiligo and provides a practical guide for application of these techniques. Results and Conclusion Our ability to treat vitiligo may be imperfect, but through appropriate patient selection and careful application of one or more of these advanced therapies, successful treatment of vitiligo, even in patients refractory to treatment, can be achieved.
机译：背景白癜风是一种获得性多灶性和多基因性色差症，影响全世界1％至3％，并表现为多个脱色素斑和斑块。传统上，白癜风的治疗主要集中在药物干预上，但几乎所有接受治疗的患者中有一半无法成功做出反应。目的存在几种可以帮助皮肤科医生治疗对传统药物治疗无效的白癜风的先进技术。这些先进的干预措施包括使用308 nm准分子激光，使用对苯二酚单苄基醚进行全身色素沉着治疗，微晶换肤，微色素沉着，khellin-UVA治疗，以及使用微型穿孔嫁接，吸水泡嫁接和表皮培养的外科手术管理。材料和方法本文回顾了有关白癜风这些先进治疗方式的最新文献，并为应用这些技术提供了实用指南。结果与结论我们治疗白癜风的能力可能并不完善，但是通过适当的患者选择和谨慎应用这些先进疗法中的一种或多种，​​即使在难以治疗的患者中也可以成功治疗白癜风。

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