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首页> 外文期刊>Hormone research in p?diatrics >Height gain at adult-height age in 184 short patients treated with growth hormone from prepubertal age to near adult-height age is not related to GH secretory status at GH therapy onset
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Height gain at adult-height age in 184 short patients treated with growth hormone from prepubertal age to near adult-height age is not related to GH secretory status at GH therapy onset

机译：从青春期前到成年身高年龄之间接受生长激素治疗的184名短期患者中，成年身高的身高增加与GH治疗开始时的GH分泌状态无关

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Background: GH release after stimuli classifies short children as severe idiopathic isolated GH deficiency (IIGHD), mild IIGHD, dissociated GH release (DGHR) and normal GH release (NGHR) and anthropometric birth data as adequate for gestational age (AGA) or small for gestational age (SGA). GH release after stimuli classifies AGA patients as IIGHD or as idiopathic short stature (ISS). Aim: To compare height gain induced by GH therapy (31.8 ± 3.5 μg/kg/day, 7.7 ± 1.6 years) started at prepubertal age and stopped at near adult-height age. Methods: A retrospective longitudinal multicenter study including 184 short patients classified as severe IIGHD n = 25, mild IIGHD n = 75, DGHR n = 55 and NGHR n = 29; or as IIGHD n = 78, ISS n = 57 and SGA n = 49. Height gain was evaluated throughout GH therapy and at adult-height age. Results: Height-SDS gain at adult-height age was similar among severe IIGHD (1.8 ± 0.8 SDS), mild IIGHD (1.6 ± 0.6 SDS), DGHR (1.7 ± 0.7 SDS) and NGHR (1.6 ± 0.7 SDS), or among IIGHD (1.7 ± 0.7 SDS), ISS (1.7 ± 0.6 SDS) and SGA (1.6 ± 0.8 SD). Conclusion: GH-release stimuli are of little help for deciding on GH therapy in the clinical management of prepubertal children with IIGHD, ISS or SGA.
机译：背景：刺激后的GH释放将矮小儿童分为严重的特发性孤立性GH缺乏症（IIGHD），轻度IIGHD，游离的GH释放（DGHR）和正常的GH释放（NGHR），以及适合胎龄（AGA）或对于胎龄较小的人体测量出生数据胎龄（SGA）。刺激后GH释放将AGA患者分类为IIGHD或特发性矮小身材（ISS）。目的：比较生长激素治疗引起的身高增加（31.8±3.5μg/ kg /天，7.7±1.6岁）始于青春期前，直至成年身高时才停止。方法：一项回顾性纵向多中心研究，包括184名短期患者，其分类为严重IIGHD n = 25，轻度IIGHD n = 75，DGHR n = 55和NGHR n = 29;或当IIGHD n = 78，ISS n = 57和SGA n = 49时。在整个GH治疗期间和成年身高年龄都对身高增加进行了评估。结果：重度IIGHD（1.8±0.8 SDS），轻度IIGHD（1.6±0.6 SDS），DGHR（1.7±0.7 SDS）和NGHR（1.6±0.7 SDS）在成人身高年龄时身高SDS增高或IIGHD（1.7±0.7 SDS），ISS（1.7±0.6 SDS）和SGA（1.6±0.8 SD）。结论：生长激素释放刺激对于IIGHD，ISS或SGA的青春期儿童临床治疗中决定GH治疗的帮助很小。

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