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首页> 外文期刊>Hormone research in p?diatrics >Growth hormone secretory status evaluated by growth hormone peak after two pharmacological growth hormone release stimuli did not significantly influence the two-year catch-up growth induced by growth hormone therapy in 318 prepubertal short children with idiopathic growth retardation
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Growth hormone secretory status evaluated by growth hormone peak after two pharmacological growth hormone release stimuli did not significantly influence the two-year catch-up growth induced by growth hormone therapy in 318 prepubertal short children with idiopathic growth retardation

机译：两种药理生长激素释放刺激后，通过生长激素峰评估的生长激素分泌状态对318名青春期前特发性矮小儿童的生长激素疗法诱导的两年追赶生长没有显着影响。

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Background/Aims: In prepubertal short children with idiopathic growth retardation, growth hormone (GH) peak after GH release stimuli classifies patients as growth hormone- deficient (GHD) or non-GHD. This study compared a 2-year growth response to GH therapy in 318 prepubertal short children. Methods: Patients were classified as: severe GHD (GH peaks <5 ng/ml after 2 stimuli; n = 54), mild GHD (GH peaks <10 ng/ml, but one or two between 5 and 10 ng/ml; n = 140), dissociated GH release (GH peak ≥10 ng/ml after 1 stimulus and <10 ng/ml after the other; n = 89), and normal GH release (GH peaks ≥10 ng/ml after 2 stimuli; n = 35). Results: Two-year height gain did not differ statistically among the 4 groups: 1.39 ± 0.51 SD, 16.4 ± 2.3 cm; 1.23 ± 0.56 SD, 15.8 ± 2.1 cm; 1.18 ± 0.53 SD, 15.3 ± 2.0 cm, and 1.14 ± 0.53 SD, 15.4 ± 2.0 cm, respectively, as was also the case for bone age gain: 2.5 ± 0.6, 2.4 ± 0.7, 2.6 ± 0.7 and 2.3 ± 0.5 years, respectively. Conclusions: Our results suggest that GH release stimuli are of little help for deciding on GH therapy in the clinical management of prepubertal short children with idiopathic growth retardation, while well-defined anthropometric and biochemical criteria may be useful.
机译：背景/目的：在患有特发性发育迟缓的青春期前矮小儿童中，GH释放刺激后的生长激素（GH）峰值将患者分类为生长激素缺乏症（GHD）或非GHD。这项研究比较了318名青春期前矮小儿童对GH治疗的2年生长反应。方法：将患者分为以下几类：重度GHD（2次刺激后GH峰值<5 ng / ml; n = 54），轻度GHD（GH峰值<10 ng / ml，但5至10 ng / ml之一或2; n = 140），解离的GH释放（1次刺激后GH峰≥10ng / ml，另一刺激后<10 ng / ml; n = 89）和正常GH释放（2次刺激后GH峰≥10ng / ml; n = 35）。结果：两组的两年身高增长无统计学差异：1.39±0.51 SD，16.4±2.3 cm; 1.23±0.56 SD，15.8±2.1厘米;骨龄增加的情况分别为1.18±0.53 SD，15.3±2.0 cm和1.14±0.53 SD，15.4±2.0 cm，分别是2.5±0.6、2.4±0.7、2.6±0.7和2.3±0.5岁，分别。结论：我们的结果表明，GH释放刺激对于在患有特发性发育迟缓的青春期前矮小儿童的临床治疗中决定GH治疗没有什么帮助，而明确的人体测量学和生化指标可能有用。

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