• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hormone research in p?diatrics >Influence of polymorphisms in genes encoding for insulin-like growth factor (IGF)-I, Insulin, and IGF-binding protein (IGFBP)-3 on IGF-I, IGF-II, and IGFBP-3 levels in umbilical cord plasma
【24h】

Influence of polymorphisms in genes encoding for insulin-like growth factor (IGF)-I, Insulin, and IGF-binding protein (IGFBP)-3 on IGF-I, IGF-II, and IGFBP-3 levels in umbilical cord plasma

机译：编码胰岛素样生长因子（IGF）-I，胰岛素和IGF结合蛋白（IGFBP）-3的基因多态性对脐带血浆中IGF-I，IGF-II和IGFBP-3的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background/Aims: In postnatal life, polymorphisms in the promoter region of IGFBP3 were associated with insulin-like growth factor binding protein (IGFBP)-3 plasma levels. Whether these associations exist in utero has not been studied yet. Polymorphisms in the IGF1 promoter (polymorphic CA-repeat) and the insulin gene variable number tandem repeats locus (INS VNTR) are further polymorphisms of interest, because associations with birth weight have been reported. We aimed to investigate associations between polymorphisms in the promoter regions of IGF1 (wild type 192 bp), IGFBP3 (rs2854744; rs13241830), and INS VNTR (rs689) with cord plasma levels of IGF-I, IGF-II, and IGFBP-3. Methods: We measured IGF-I, IGF-II, and IGFBP-3 concentrations in cord blood from 677 neonates and genotyped the selected polymorphisms. Results: Carriers of the minor allele of both polymorphisms in the IGFBP3 gene had, on average, 4-5% lower IGFBP-3 levels per copy of the respective minor allele (p = 0.002 and p = 0.028) when compared to wild type carriers. The IGF1 promoter and the INS VNTR polymorphisms were not associated with IGF-I, IGF-II, or IGFBP-3 levels. Conclusions: Our data show associations of cord plasma IGFBP-3 levels and the IGFBP3 gene variants but not of IGF1 promoter and INS VNTR polymorphisms with IGF-I, IGF-II, or IGFBP-3 levels in utero.
机译：背景/目的：在出生后的生命中，IGFBP3启动子区域的多态性与胰岛素样生长因子结合蛋白（IGFBP）-3血浆水平有关。这些关联在子宫内是否存在尚未进行研究。 IGF1启动子（多态CA重复）和胰岛素基因可变数目串联重复基因座（INS VNTR）的多态性是人们感兴趣的其他多态性，因为已经报道了与出生体重的关系。我们旨在研究IGF1（野生型192 bp），IGFBP3（rs2854744; rs13241830）和INS VNTR（rs689）启动子区域中的多态性与IGF-I，IGF-II和IGFBP-3脐带血浆水平的关联。方法：我们测量了来自677名新生儿的脐带血中的IGF-I，IGF-II和IGFBP-3浓度，并对选定的多态性进行了基因分型。结果：与野生型携带者相比，IGFBP3基因中两个多态性的次要等位基因携带者每拷贝相应的次要等位基因的平均IGFBP-3水平平均降低4-5％（p = 0.002和p​​ = 0.028） 。 IGF1启动子和INS VNTR多态性与IGF-I，IGF-II或IGFBP-3水平无关。结论：我们的数据显示脐带血浆IGFBP-3水平与IGFBP3基因变异相关，但IGF1启动子和INS VNTR多态性与子宫内IGF-I，IGF-II或IGFBP-3水平无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号