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首页> 外文期刊>Dermatology: international journal for clinical and investigative dermatology >Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate.
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Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate.

机译：继发性梅毒皮肤病变中的梅毒螺旋体的检测和炎性浸润的特征。

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摘要

BACKGROUND: Syphilis is an ancient sexually transmitted disease. However, the pathogenesis of mucocutaneous lesions of secondary syphilis is not completely understood. METHODS: We analyzed the presence of Treponema pallidum in formalin-fixed, paraffin-embedded biopsy specimens from mucocutaneous lesions of secondary syphilis using highly sensitive nested polymerase chain reaction (PCR). The inflammatory infiltrates from the same specimens are also characterized using immunohistochemical methods. RESULTS AND CONCLUSIONS: Ten out of 24 (41.7%) specimens are T. pallidum positive using nested PCR, whereas none of them is T. pallidum positive using traditional silver staining. The presence of T. pallidum in the mucocutaneous lesions indicates that mucocutaneous lesions of secondary syphilis might be caused by direct T. pallidum invasion rather than by an allergic reaction. Furthermore, the majority of inflammatory infiltrating cells are CD45RO-positive T cells and CD68-positive macrophages, suggesting that cellular immunity plays an important role in the host reaction against T. pallidum infection in secondary syphilis.
机译：背景：梅毒是一种古老的性传播疾病。然而，继发性梅毒的粘膜皮肤病变的发病机理尚不完全清楚。方法：我们使用高度敏感的巢式聚合酶链反应（PCR）分析了福尔马林固定，石蜡包埋的继发性梅毒皮损的活检标本中存在梅毒螺旋体。还使用免疫组织化学方法对来自相同标本的炎性浸润进行了表征。结果与结论：24个样本中有十个样本（41.7％）采用巢式PCR检定为梅毒螺旋体阳性，而传统银染方法均未检出梅毒螺旋体阳性。在皮肤粘膜病变中存在苍白螺旋体表明，继发性梅毒的皮肤粘膜病变可能是由直接的苍白螺旋体侵袭而非过敏反应引起的。此外，大多数炎性浸润细胞是CD45RO阳性T细胞和CD68阳性巨噬细胞，表明细胞免疫在继发性梅毒中抵抗苍白球菌感染的宿主反应中起着重要作用。

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