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首页> 外文期刊>Dermatology: international journal for clinical and investigative dermatology >Tacrolimus-induced rosacea-like dermatitis: A clinical analysis of 16 cases associated with tacrolimus ointment application
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Tacrolimus-induced rosacea-like dermatitis: A clinical analysis of 16 cases associated with tacrolimus ointment application

机译：他克莫司诱导的酒渣鼻样皮炎：他克莫司软膏应用16例临床分析

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摘要

Background: Recently, reports have indicated that the continuous use of topical calcineurin inhibitors such as tacrolimus may induce rosacea-like dermatitis (RD). Objective and Methods: To assess clinical features of RD associated with tacrolimus, 44 cases of patients diagnosed with RD between 2005 and 2010 at our hospital were retrospectively reviewed. Results: In total, 22 cases were caused by topical steroid use, 8 by topical tacrolimus use, and 8 by consecutive treatment with topical steroids and tacrolimus. Clinical presentation was basically similar among the 3 groups, although the nose was less frequently affected and pustules were rarely observed in the latter 2 sets of cases. Demodex mites were often found in smears of skin lesions from patients with RD caused by steroids and tacrolimus. Treatment with topical metronidazole was effective in most RD patients. Conclusion: Topical tacrolimus is becoming an important cause of RD along with topical steroids.
机译：背景：最近，有报道表明，持续使用局部钙调神经磷酸酶抑制剂（如他克莫司）可能会引起酒渣鼻样皮炎（RD）。目的与方法：回顾性分析2005年至2010年我院收治的他克莫司相关性RD的临床特征，共44例。结果：总共有22例由局部类固醇使用引起，8例由局部他克莫司使用引起，8例由局部类固醇和他克莫司连续治疗引起。三组之间的临床表现基本相似，尽管在后两组病例中鼻子受影响的频率较低，脓疱很少见。在类固醇和他克莫司引起的RD患者皮肤病变涂片中经常发现蠕形螨。局部甲硝唑治疗对大多数RD患者有效。结论：局部他克莫司与局部类固醇一起成为RD的重要原因。

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