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首页> 外文期刊>Development >The C. elegans developmental timing protein LIN-42 regulates diapause in response to environmental cues.
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The C. elegans developmental timing protein LIN-42 regulates diapause in response to environmental cues.

机译：秀丽隐杆线虫发育时间蛋白LIN-42调节滞育反应对环境的提示。

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摘要

Environmental conditions can have a major impact on developmental progression in animals. For example, when C. elegans larvae encounter harsh conditions they can reversibly halt the passage of developmental time by forming a long-lived dauer larva at the end of the second larval stage. Here, we show that the period homolog lin-42, known to control developmental time, also acts as a component of a switch that mediates dauer entry. Loss of lin-42 function renders animals hypersensitive to dauer formation under stressful conditions, whereas misexpression of lin-42 in the pre-dauer stage inhibits dauer formation, indicating that lin-42 acts as a negative regulator of this life history decision. These phenotypes place LIN-42 in opposition to the ligand-free form of the nuclear receptor DAF-12, which indirectly senses environmental conditions and helps to integrate external cues into developmental decisions. Mutations that impair DAF-12 ligand binding are exquisitely sensitive to the absence of lin-42, whereas overexpression of LIN-42 can suppress the dauer constitutive phenotype of a ligand-insensitive daf-12 mutant, suggesting that LIN-42 and DAF-12 are intimate partners in controlling the decision to become a dauer larva. The functional outputs of Period family proteins and nuclear receptors also converge in other organisms, suggesting that the relationship between lin-42 and daf-12 represents an ancient genetic framework for responding to environmental stimuli.
机译：环境条件可能会对动物的发育进程产生重大影响。例如，当秀丽隐杆线虫幼虫遇到恶劣条件时，它们可以通过在第二个幼虫阶段结束时形成长寿的幼虫来逆转地停止发育时间的流逝。在这里，我们显示了已知控制发育时间的同系物lin-42，它也充当介导dauer进入的开关的组成部分。 lin-42功能的丧失使动物在压力条件下对dauer的形成高度敏感，而在pre-dauer阶段lin-42的错误表达抑制了dauer的形成，表明lin-42充当了这一生活史决定的负向调节器。这些表型将LIN-42与核受体DAF-12的无配体形式相对，后者间接感知环境条件，并有助于将外部线索整合到发展决策中。损害DAF-12配体结合的突变对lin-42的缺失非常敏感，而LIN-42的过表达可以抑制对配体不敏感的daf-12突变体的dauer本构表型，这表明LIN-42和DAF-12是控制成为幼仔的亲密伙伴。周期家族蛋白和核受体的功能输出也在其他生物中融合，这表明lin-42和daf-12之间的关系代表了一种古老的遗传框架，可以响应环境刺激。

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