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A germline-centric view of cell fate commitment, reprogramming and immortality

机译:以生殖系为中心的细胞命运承诺,重编程和永生性视图

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摘要

To ensure species continuity, the tantalising developmental plasticity of early embryonic cells, also called totipotency, must be transmitted to the offspring. This responsibility rests within the reproductive cell lineage: the germ line. At the recent EMBO/EMBL symposium 'Germline - Immortality through Totipotency', researchers discussed the mechanisms that establish and control totipotency, with an eye towards the mechanisms that may endow germ cells with the ability to propagate totipotency across generations.
机译:为了确保物种的连续性,必须将早期胚胎细胞诱人的发育可塑性(也称为全能)传递给后代。这种责任在于生殖细胞谱系:种系。在最近的EMBO / EMBL研讨会“ Germline-通过全能永生”中,研究人员讨论了建立和控制全能的机制,着眼于赋予生殖细胞跨代传播全能能力的机制。

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