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Cyclic AMP in oocytes controls meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary

机译：卵母细胞中的环状AMP控制围生期小鼠卵巢的减数分裂前期I和原始卵泡形成

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摘要

In mammalian ovaries, a fixed population of primordial follicles forms during the perinatal stage and the oocytes contained within are arrested at the dictyate stage of meiotic prophase I. In the current study, we provide evidence that the level of cyclic AMP ( cAMP) in oocytes regulates oocyte meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary. Our results show that the early meiotic development of oocytes is closely correlated with increased levels of intra-oocyte cAMP. Inhibiting cAMP synthesis in fetal ovaries delayed oocyte meiotic progression and inhibited the disassembly and degradation of synaptonemal complex protein 1. In addition, inhibiting cAMP synthesis in in vitro cultured fetal ovaries prevented primordial follicle formation. Finally, using an in situ oocyte chromosome analysis approach, we found that the dictyate arrest of oocytes is essential for primordial follicle formation under physiological conditions. Taken together, these results suggest a role for cAMP in early meiotic development and primordial follicle formation in the mouse ovary.
机译：在哺乳动物卵巢中，围产期形成原始卵泡的固定群体，并且卵母细胞在减数分裂前期I的独立阶段被阻滞。在本研究中，我们提供了证据，表明卵母细胞中环AMP（cAMP）的水平调节围产期小鼠卵巢的卵母细胞减数分裂前期I和原始卵泡形成。我们的结果表明，卵母细胞的早期减数分裂发育与卵内cAMP水平升高密切相关。在胎儿卵巢中抑制cAMP合成可延缓卵母细胞的减数分裂进程，并抑制突触复合蛋白1的分解和降解。此外，在体外培养的胎儿卵巢中抑制cAMP合成可防止原始卵泡的形成。最后，使用原位卵母细胞染色体分析方法，我们发现在生理条件下，卵母细胞的单方面停滞对于原始卵泡的形成至关重要。两者合计，这些结果表明cAMP在小鼠卵巢的早期减数分裂发育和原始卵泡形成中的作用。

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