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首页> 外文期刊>Development >Dual role of the Pax gene paired in accessory gland development of Drosophila.
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Dual role of the Pax gene paired in accessory gland development of Drosophila.

机译：Pax基因配对在果蝇附属腺发育中的双重作用。

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摘要

The Drosophila Pax gene paired encodes a transcription factor that is required for the activation of segment-polarity genes and proper segmentation of the larval cuticle, postembryonic viability and male fertility. We show that paired executes a dual role in the development of male accessory glands, the organ homologous to the human prostate. An early function is necessary to promote cell proliferation, whereas a late function, which regulates the expression of accessory gland products such as the sex peptide and Acp26Aa protein, is essential for maturation and differentiation of accessory glands. The late function exhibits in main and secondary secretory cells of accessory glands dynamic patterns of Paired expression that depend in both cell types on the mating activity of adult males, possibly because Paired expression is regulated by negative feedback. The early Paired function depends on domains or motifs in its C-terminal moiety and the late function on the DNA-binding specificity of its N-terminal paired-domain and/or homeodomain. Both Paired functions are absolutely required for male fertility, and both depend on an enhancer located within 0.8 kb of the downstream region of paired.
机译：果蝇Pax基因配对编码转录因子，该转录因子是激活节段极性基因和适当分割幼虫表皮，胚胎后活力和雄性育性所必需的。我们显示，配对在雄性腺体（与人类前列腺同源的器官）的发育中执行双重作用。早期功能是促进细胞增殖所必需的，而后期功能则是调节附属腺产物（如性肽和Acp26Aa蛋白）的表达，对于附属腺的成熟和分化至关重要。晚期功能在副腺的主要和次要分泌细胞中表现出成对表达的动态模式，这取决于两种细胞类型取决于成年雄性的交配活性，这可能是因为成对表达受负反馈调节。早期配对功能取决于其C末端部分的结构域或基序，而后期配对功能取决于其N末端配对结构域和/或同源域的DNA结合特异性。配对功能对于雄性育性是绝对必需的，并且都取决于位于配对下游区域0.8 kb内的增强子。

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