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首页> 外文期刊>Development >Drosophila homeodomain protein Nkx6 coordinates motoneuron subtype identity and axonogenesis.
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Drosophila homeodomain protein Nkx6 coordinates motoneuron subtype identity and axonogenesis.

机译：果蝇homeodomain蛋白Nkx6协调运动神经元亚型的同一性和轴突发生。

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The regulatory networks acting in individual neurons to control their stereotyped differentiation, connectivity, and function are not well understood. Here, we demonstrate that homeodomain protein Nkx6 is a key member of the genetic network of transcription factors that specifies neuronal fates in Drosophila. Nkx6 collaborates with the homeodomain protein Hb9 to specify ventrally projecting motoneuron fate and to repress dorsally projecting motoneuron fate. While Nkx6 acts in parallel with hb9 to regulate motoneuron fate, we find that Nkx6 plays a distinct role to promote axonogenesis, as axon growth of Nkx6-positive motoneurons is severely compromised in Nkx6 mutant embryos. Furthermore, Nkx6 is necessary for the expression of the neural adhesion molecule Fasciclin III in Nkx6-positive motoneurons. Thus, this work demonstrates that Nkx6 acts in a specific neuronal population to link neuronal subtype identity to neuronal morphology and connectivity.
机译：在单个神经元中起作用以控制其定型分化，连通性和功能的调节网络尚不清楚。在这里，我们证明同源域蛋白Nkx6是转录因子基因网络的关键成员，该基因指定了果蝇的神经元命运。 Nkx6与同源结构域蛋白Hb9共同确定腹侧投射的运动神经元命运，并抑制背侧投射的运动神经元命运。虽然Nkx6与hb9并行作用来调节运动神经元的命运，但我们发现Nkx6在促进轴突发生中起着独特的作用，因为Nkx6阳性运动神经元的轴突生长在Nkx6突变体胚胎中受到严重损害。此外，Nkx6是神经粘附分子Fasciclin III在Nkx6阳性运动神经元中表达所必需的。因此，这项工作证明Nkx6在特定的神经元群体中起作用，将神经元亚型的同一性与神经元的形态和连通性联系起来。

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