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首页> 外文期刊>Development >Repression of Dpp targets in the Drosophila wing by Brinker.
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Repression of Dpp targets in the Drosophila wing by Brinker.

机译：Brinker抑制果蝇翅膀中的Dpp目标。

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摘要

Patterning along developing body axes is regulated by gradients of transcription factors, which activate or repress different genes above distinct thresholds. Understanding differential threshold responses requires knowledge of how these factors regulate transcription. In the Drosophila wing, expression of genes such as omb and sal along the anteroposterior axis is restricted by lateral-to-medial gradients of the transcriptional repressor Brinker (Brk). omb is less sensitive to repression by Brk than sal and is consequently expressed more laterally. Contrary to previous suggestions, we show that Brk cannot repress simply by competing with activators, but requires specific repression domains along with its DNA-binding domain. Brk possesses at least three repression domains, but these are not equivalent; one, 3R, is sufficient to repress omb but not sal. Thus, although sal and omb show quantitative differences in their response to Brk, there are qualitative differences in the mechanisms that Brk uses to repress them.
机译：沿着发育中的身体轴的模式受转录因子梯度的调节，转录因子可激活或抑制高于不同阈值的不同基因。了解差异阈值响应需要了解这些因素如何调节转录。在果蝇的机翼中，转录抑制基因Brinker（Brk）的横向-中间梯度限制了诸如omb和sal沿前后轴的基因表达。 omb对Brk抑制的敏感性不如sal敏感，因此在横向上表达更多。与先前的建议相反，我们表明Brk不能仅通过与激活剂竞争来阻遏，而是需要特定的阻遏域及其DNA结合域。 Brk至少具有三个抑制域，但并不相同。一个是3R，足以抑制omb，但不能抑制sal。因此，尽管sal和omb在对Brk的反应中显示出数量上的差异，但是Brk用来抑制它们的机制却存在质的差异。

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