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首页> 外文期刊>Development and psychopathology >Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and μ-opioid receptor M1 variation
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Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and μ-opioid receptor M1 variation

机译：从发展的角度测试酒精中毒的代际传播中的多种影响水平：以酒精使用促进同伴和μ阿片受体M1变异为例

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This study examined the interplay between the influence of peers who promote alcohol use and 1/4-opioid receptor M1 (OPRM1) genetic variation in the intergenerational transmission of alcohol use disorder (AUD) symptoms while separating the traitlike components of AUD symptoms from their age-specific manifestations at three ages from emerging adulthood (17-23 years) to adulthood (29-40 years). The results for males were consistent with genetically influenced peer selection mechanisms as mediators of parent alcoholism effects. Male children of alcoholics were less likely to be carriers of the G allele in single nucleotide polymorphism A118G (rs1799971), and those who were homozygous for the A allele were more likely to affiliate with alcohol use promoting peers who increased the risk for AUD symptoms at all ages. There was evidence for women of an interaction between OPRM1 variation and peer affiliations but only at the earliest age band. Peer influences had stronger effects among women who were G-carriers. These results illustrate the complex ways in which the interplay between influences at multiple levels of analysis can underlie the intergenerational transmission of alcohol disorders as well as the importance of considering age and gender differences in these pathways.
机译：这项研究检验了促进饮酒的同龄人与1/4阿片类受体M1（OPRM1）遗传变异在饮酒障碍（AUD）症状的代际传播之间的相互影响，同时从年龄中区分了AUD症状的特质成分从新兴成年（17-23岁）到成年（29-40岁）的三个年龄的特定表现。男性的结果与遗传影响的同伴选择机制作为父母酗酒效应的中介者一致。酗酒的男性儿童不太可能是单核苷酸多态性A118G（rs1799971）中G等位基因的携带者，而那些A等位基因纯合子的儿童则更可能与促进酗酒的同伴联系在一起，从而增加了AUD症状的风险。所有年龄段。有证据表明妇女的OPRM1变异与同伴之间存在相互作用，但仅在最早的年龄段。同伴影响在携带G的女性中影响更大。这些结果说明了在多种分析水平上影响之间相互作用的复杂方法可以成为酒精障碍的代际传播的基础，以及在这些途径中考虑年龄和性别差异的重要性。

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