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首页> 外文期刊>Developmental Medicine and Child Neurology >The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies
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The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies

机译：哌醋甲酯对注意缺陷多动障碍和难治性癫痫儿童的癫痫发作频率和严重程度的影响

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SIR-Santos et al. convincingly demonstrate that methyl-phenidate (MPH) is effective in improving attention-defl-cit-hyperactivity disorder symptoms in children with active seizure disorders. Among a group of 163 individuals with Dravet syndrome, a difficult-to-treat epilepsy, we recently showed that up to two-thirds of children have inattention/ hyperactivity symptoms, highlighting that treatment with MPH might be a valuable contribution in their management. However, the study design of Santos et al. does not allow a conclusion that MPH improves seizure severity. The study had a 3 -month baseline period without MPH followed by a 3-month trial period with MPH.
机译：SIR-桑托斯等。令人信服地证明，哌醋甲酯（MPH）可有效改善患有活动性癫痫病的儿童的注意力缺陷，多动症，多动症。最近，在一组163例患有难治性癫痫病的Dravet综合征患者中，我们最近发现多达三分之二的儿童患有注意力不集中/多动症，这表明MPH的治疗可能对他们的治疗非常有价值。然而，桑托斯等人的研究设计。不能得出MPH可改善癫痫发作严重程度的结论。该研究的基线期为3个月，无MPH，随后为3个月，为MPH。

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