...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Diabetes care >Traditional risk factors alone could not explain the excess mortality in patients with diabetes: A national cohort study of older Spanish adults
【24h】

Traditional risk factors alone could not explain the excess mortality in patients with diabetes: A national cohort study of older Spanish adults

机译：仅传统的危险因素就不能解释糖尿病患者的高死亡率：一项针对西班牙老年人的国家队列研究

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE - Individuals with diabetes have an excessmortality compared with people without diabetes. This study used a national cohort of older Spanish adults to identify possible factors explaining the relation between diabetes and excess mortality. RESEARCH DESIGN AND METHODS - A cohort of 4,008 people ≥60 years of age was selected in 2000-2001 and followed prospectively until 2008. At baseline, data were collected on diabetes and major risk factors for mortality: social network, diet, physical activity and other lifestyle factors, obesity, hypertension, dyslipidemia, and previous cardiovascular disease and cancer. Analyses were conducted with Cox regression with progressive adjustment for mortality risk factors. RESULTS - In the study cohort, 667 people had diabetes. A total of 972 deaths occurred during follow-up. The hazard ratio (HR) and 95% CI for mortality in diabetic versus nondiabetic subjects, adjusted for age, marital status, education level, social class, medical consultation, and treatment with statins, angiotensin II antagonists, or aspirin, was 1.40 (1.11-1.76) in men and 1.70 (1.37-2.10) in women. Adjustment for additional risk factors produced little change in the HR. After adjustment for all risk factors, including cardiovascular disease and cancer, the mortality HR in diabetic versus nondiabetic individuals was 1.43 (1.12-1.82) in men and 1.67 (1.34-2.08) in women. The inclusion of lifestyles and diseases occurring during follow-up also produced little change in the relation between diabetes and mortality. CONCLUSIONS - The excess risk of mortality in diabetic versus nondiabetic individuals cannot be explained by mortality risk factors or by the presence of cardiovascular disease or cancer.
机译：目的-与非糖尿病患者相比，糖尿病患者的死亡率高。这项研究使用西班牙老年人的国家队列来确定可能的因素，以解释糖尿病与超额死亡率之间的关系。研究设计与方法-从2000年至2001年，选择了4,008名≥60岁的人群，并随访至2008年。在基线时，收集了有关糖尿病和主要死亡风险因素的数据：社交网络，饮食，身体活动和其他生活方式因素，肥胖，高血压，血脂异常以及以前的心血管疾病和癌症。使用Cox回归进行分析，逐步调整死亡率危险因素。结果-在该研究队列中，有667人患有糖尿病。随访期间共发生972例死亡。经年龄，婚姻状况，教育水平，社会阶层，医疗咨询以及他汀类药物，血管紧张素II拮抗剂或阿司匹林治疗后，在糖尿病和非糖尿病受试者中，死亡率的危险比（HR）和95％CI为1.40（1.11）男性为-1.76），女性为1.70（1.37-2.10）。调整其他风险因素后，HR的变化很小。在对所有危险因素（包括心血管疾病和癌症）进行调整后，糖尿病与非糖尿病患者的死亡率HR在男性中为1.43（1.12-1.82），在女性中为1.67（1.34-2.08）。在随访期间将生活方式和疾病包括在内也几乎没有改变糖尿病与死亡率之间的关系。结论-糖尿病和非糖尿病患者的死亡风险过高不能通过死亡风险因素或心血管疾病或癌症的存在来解释。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号