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首页> 外文期刊>Diabetes care >Estimation of the glycation gap in diabetic patients with stable glycemic control
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Estimation of the glycation gap in diabetic patients with stable glycemic control

机译：稳定血糖控制的糖尿病患者糖化间隙的估计

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OBJECTIVE - The glycation gap (the difference between measured A1C and the value predicted by regression on fructosamine) is stable and is associated with microvascular complications of diabetes but has not hitherto been estimated within a clinically useful time frame. We investigated whether two determinations 30 days apart suffice for a reasonably reliable estimate if both A1C and fructosamine exhibit stability. RESEARCH DESIGN ANDMETHODS - We studied 311 patients with type 1 or type 2 diabetes for whom simultaneous measurements of A1C and serum fructosamine had been made on at least two occasions separated by 1 month (t0 and t1). Glycemia was deemed stable if A1C(t1) -A1C(t0) and fructosamine(t1) - fructosamine(t0) were both less than their reference change values (RCVs). Instantaneous glycation gaps [gg(t0) and gg(t1)] and their mean (GG), were calculated using the data from all stable patients for the required regression. RESULTS - Stable glycemia was shown by 144 patients. In 90% of unstable case subjects, a change inmedication was identified as the cause of instability. Among 129 stable patients with an average of eight gg determinations prior to t0, GG correlated closely with the mean of these prior determinations (r2 = 0.902, slope 1.025, intercept -0.038). CONCLUSIONS - The glycation gap can be calculated reliably from pairs of A1C and fructosamine measurements taken 1 month apart if these measurements satisfy the RCV criteria for glycemic control.
机译：目的-糖化差距（糖化差距（测得的A1C与果糖胺回归预测的值之间的差））稳定且与糖尿病的微血管并发症有关，但迄今尚未在临床有用的时间范围内进行估计。我们调查了相隔30天的两次测定是否足以可靠地估算A1C和果糖胺是否都表现出稳定性。研究设计和方法-我们研究了311例1型或2型糖尿病患者，至少在两次间隔1个月的情况下（t0和t1）对A1C和血清果糖胺进行了同时测量。如果A1C（t1）-A1C（t0）和果糖胺（t1）-果糖胺（t0）均小于参考变化值（RCV），则认为血糖稳定。瞬时糖基化缺口[gg（t0）和gg（t1）]及其平均值（GG），是使用所有稳定患者所需回归数据得出的。结果-144名患者显示出稳定的血糖。在90％的不稳定病例中，适应症的变化被确定为不稳定的原因。在t0之前平均进行8次gg测定的129位稳定患者中，GG与这些先前测定的平均值密切相关（r2 = 0.902，斜率1.025，截距-0.038）。结论-如果糖化间隙可以满足RCV血糖控制标准，则可以从间隔1个月的A1C和果糖胺对中可靠地计算出糖化间隙。

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