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首页> 外文期刊>Diabetes care >Relationship between retinal blood flow and renal function in patients with type 2 diabetes and chronic kidney disease
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Relationship between retinal blood flow and renal function in patients with type 2 diabetes and chronic kidney disease

机译：2型糖尿病合并慢性肾脏病患者视网膜血流与肾功能的关系

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OBJECTIVE-To study the relationship between retinal microcirculation and renal function in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS-Using a laser Doppler velocimetry system, we obtained the retinal blood flow (RBF) values by simultaneously measuring the retinal vessel diameter and blood velocity. To determine if the RBF is affected in the presence of renal dysfunction, we also evaluated the renal function using the estimated glomerular filtration rate calculated by age and serum creatinine level. RESULTS-We recruited 169 eyes of 169 consecutive Japanese patients with type 2 diabetes, no or minimal diabetic retinopathy, and normo/microalbuminuria (mean age??SD, 59.0??11.1 years). We divided the patients into four groups based on the stage of chronic kidney disease (CKD) (non-CKD, n = 99; CKD stage 1, n = 22; stage 2, n = 27; stage 3, n = 21). We found significant (P = 0.035) decreases in RBF with decreased vessel diameter (P = 0.017) but no difference in blood velocity (P = 0.54) in stage 3 CKD compared with the non-CKD group. Multiple regression analysis showed that the CKD stage was significantly (P = 0.02) and independently associated with decreased RBF. CONCLUSIONS-Our results indicated that the vessel diameter and RBF in the retinal arterioles decrease in patients with type 2 diabetes with stage 3 CKD, suggesting that impaired renal function might be associated with decreased RBF, probably via constriction of the retinal arterioles, in early-phase diabetic retinopathy. ? 2013 by the American Diabetes Association.
机译：目的-研究2型糖尿病患者视网膜微循环与肾功能的关系。研究设计和方法-使用激光多普勒测速系统，我们通过同时测量视网膜血管直径和血流速度来获得视网膜血流（RBF）值。为了确定在肾功能不全的情况下RBF是否受到影响，我们还使用通过年龄和血清肌酐水平计算的估计肾小球滤过率评估了肾功能。结果-我们招募了连续169例日本2型糖尿病，无或最小的糖尿病性视网膜病变和正常/微量白蛋白尿（平均年龄51.0±11.1岁）的169眼。我们根据慢性肾脏病（CKD）的阶段将患者分为四组（非CKD，n = 99; CKD阶段1，n = 22;阶段2，n = 27;阶段3，n = 21）。我们发现，与非CKD组相比，第三阶段CKD的RBF显着降低（P = 0.035），且血管直径减小（P = 0.017），但血流速度没有差异（P = 0.54）。多元回归分析表明，CKD阶段显着（P = 0.02），并且与RBF降低独立相关。结论-我们的结果表明，在3型CKD的2型糖尿病患者中，视网膜小动脉的血管直径和RBF减小，提示肾脏功能受损可能与RBF降低有关，可能是由于视网膜小动脉收缩引起的。糖尿病性视网膜病变？ 2013年由美国糖尿病协会颁发。

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