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首页> 外文期刊>Diabetes care >Prospective associations of B-type natriuretic peptide with markers of left ventricular function in individuals with and without type 2 diabetes: An 8-year follow-up of the Hoorn Study
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Prospective associations of B-type natriuretic peptide with markers of left ventricular function in individuals with and without type 2 diabetes: An 8-year follow-up of the Hoorn Study

机译：患有和不患有2型糖尿病的个体中B型利钠肽与左心室功能标记的前瞻性关联：Hoorn研究的8年随访

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OBJECTIVE - Heart failure is common in individuals with type 2 diabetes, and early detection of individuals at risk may offer opportunities for prevention. We aimed to explore 1) prospective associations of B-type natriuretic peptide (BNP) levels in a non-heart failure range with changes in markers of left ventricular (LV) function and 2) possible effect modification by type 2 diabetes in a population-based cohort. RESEARCH DESIGN AND METHODS - Echocardiographic measurements were performed at baseline (2000-2001) and follow-up (2007-2009), together with standardized physical examinations and BNP measurements on 300 individuals (mean age 66 years, 32% with type 2 diabetes) of the longitudinal Hoorn Study. Multivariate linear regression analyses were performed to investigate associations of baseline BNP (<100 pg/mL) in individuals without prevalent heart failure at baseline with changes in LV mass index, LV ejection fraction, left atrial volume index, and ratio of early diastolic LVinflowvelocity (E) to early diastolic lengthening velocity (e′) (E/e′). RESULTS - In all individuals, higher BNP was associated with 8-year increases in left atrial volume index. Higher BNP was also associated with increasing LV mass index and E/e′. These associations were significantly stronger in individuals with type 2 diabetes compared with the nonsignificant associations in individuals without type 2 diabetes. CONCLUSIONS - This 8-year follow-up study shows that higher BNP levels in a non-heart failure range were associated with an increased LV mass and deteriorated LV diastolic function, particularly in individuals with type 2 diabetes. This implies that the presence or absence of type 2 diabetes should be taken into account if BNP levels are used to assess future heart failure risk.
机译：目的-心力衰竭在2型糖尿病患者中很常见，早期发现有风险的个体可能会提供预防的机会。我们旨在探讨1）非心力衰竭范围内B型利钠肽（BNP）水平与左心室（LV）功能标志物变化的前瞻性关联，以及2）人群中2型糖尿病可能对疗效的影响队列。研究设计和方法-在基线（2000-2001）和随访（2007-2009）进行了超声心动图测量，并对300例患者（平均年龄66岁，32％的2型糖尿病）进行了标准化的体格检查和BNP测量。霍恩纵向研究的基础。进行多元线性回归分析以研究基线时无普遍心力衰竭的个体的基线BNP（<100 pg / mL）与LV质量指数，LV射血分数，左心房容积指数和早期舒张期LVinflowvelocity速度比的变化之间的关系（ E）至舒张早期舒张速度（e'）（E / e'）。结果–在所有个体中，较高的BNP与左心房容积指数增加8年有关。较高的BNP也与LV质量指数和E / e'增加有关。与没有2型糖尿病的个体相比，这些关联在非2型糖尿病个体中明显更强。结论-这项为期8年的随访研究表明，在非心力衰竭范围内较高的BNP水平与LV质量增加和LV舒张功能恶化有关，特别是在2型糖尿病患者中。这意味着如果使用BNP水平评估未来心力衰竭风险，则应考虑2型糖尿病的存在与否。

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