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Age at menopause, reproductive life span, and type 2 diabetes risk: Results from the EPIC-InterAct study

机译：更年期年龄，生殖寿命和2型糖尿病风险：EPIC-InterAct研究的结果

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OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86- 1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and ??55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age atmenopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. ? 2013 by the American Diabetes Association.
机译：绝经年龄是未来健康结局的重要决定因素，但对其与2型糖尿病的关系知之甚少。我们研究了绝经年龄和生殖寿命（绝经年龄减去月经初潮年龄）与糖尿病风险的关系。研究设计和方法-数据来自InterAct研究，该研究是一项前瞻性病例队列研究，位于欧洲癌症与营养前瞻性研究之内。该分析共纳入了3,691名绝经后2型糖尿病患者和4,408名亚队列成员，平均随访时间为11年。调整了Prentice加权Cox比例风险模型的年龄，已知的糖尿病危险因素和生殖因素，并研究了BMI，腰围和吸烟对效果的影响。结果该亚人群的平均（SD）年龄为59.2（5.8）岁。经过多变量调整后，更年期女性的2型糖尿病风险比（HRs）为1.32（95％CI 1.04-1.69），1.09（0.90-1.31），0.97（0.86-1.10）和0.85（0.70-1.03）相对于50-54岁绝经的人，年龄分别小于40、40-44、45-49和55岁。每位SD绝经后女性的HR为1.08（1.02-1.14）。同样，较短的生殖寿命与较高的糖尿病风险相关（每SD HR较低的生殖寿命1.06 [1.01-1.12]）。未观察到BMI，腰围或吸烟引起的效果改变（P交互作用均> 0.05）。结论-绝经早期与2型糖尿病的风险更高有关。 ？ 2013年由美国糖尿病协会颁发。

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