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首页> 外文期刊>Diabetes care >Noninvasive blood glucose monitoring with optical coherence tomography: a pilot study in human subjects.
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Noninvasive blood glucose monitoring with optical coherence tomography: a pilot study in human subjects.

机译：使用光学相干断层扫描技术进行无创血糖监测：在人类受试者中的一项初步研究。

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OBJECTIVE: To study the feasibility of noninvasive blood glucose monitoring using optical coherence tomography (OCT) technique in healthy volunteers. RESEARCH DESIGN AND METHODS: An OCT system with the wavelength of 1,300 nm was used in 15 healthy subjects in 18 clinical experiments. Standard oral glucose tolerance tests were performed to induce changes in blood glucose concentration. Blood samples were taken from the right arm vein every 5 or 15 min. OCT images were taken every 10-20 s from the left forearm over a total period of 3 h. The slope of the signals was calculated at the depth of 200-600 micro m from the skin surface. RESULTS: A total of 426 blood samples and 8,437 OCT images and signals were collected and analyzed in these experiments. There was a good correlation between changes in the slope of noninvasively measured OCT signals and blood glucose concentrations throughout the duration of the experiments. The slope of OCT signals changed significantly (up to 2.8% per 10 mg/dl) with variation of plasma glucose values. The good correlation obtained between the OCT signal slope and blood glucose concentration is due to the coherent detection of backscattered photons, which allows measurements of OCT signal from a specific tissue layer without unwanted signal from other tissue layers. CONCLUSIONS: This pilot study demonstrated the capability of the OCT technique to monitor blood glucose concentration noninvasively in human subjects. Further studies with a larger number of subjects including diabetic subjects are planned to validate these preliminary results.
机译：目的：研究使用光学相干断层扫描（OCT）技术对健康志愿者进行无创血糖监测的可行性。研究设计和方法：在18个临床实验中，对15位健康受试者使用了波长为1,300 nm的OCT系统。进行标准的口服葡萄糖耐量试验以引起血糖浓度的变化。每5或15分钟从右臂静脉取一次血样。在整个3小时的时间内，每10-20 s从左前臂拍摄OCT图像。在距皮肤表面200-600微米的深度处计算信号的斜率。结果：在这些实验中收集并分析了426份血液样本和8,437张OCT图像和信号。在整个实验过程中，非侵入式测量的OCT信号的斜率变化与血糖浓度之间存在良好的相关性。随着血浆葡萄糖值的变化，OCT信号的斜率发生了显着变化（每10 mg / dl高达2.8％）。 OCT信号斜率与血糖浓度之间获得的良好相关性是由于对背向散射光子进行了相干检测，从而可以测量来自特定组织层的OCT信号而没有来自其他组织层的有害信号。结论：这项初步研究证明了OCT技术能够无创地监测人类受试者的血糖浓度。计划对包括糖尿病受试者在内的大量受试者进行进一步研究，以验证这些初步结果。

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