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首页> 外文期刊>Diabetes care >Incidence and risk factors of prolonged QTc interval in type 1 diabetes: the EURODIAB Prospective Complications Study.
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Incidence and risk factors of prolonged QTc interval in type 1 diabetes: the EURODIAB Prospective Complications Study.

机译：1型糖尿病患者QTc间隔延长的发生率和危险因素：EURODIAB前瞻性并发症研究。

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OBJECTIVE: Corrected QT (QTc) prolongation is predictive of cardiovascular mortality in both the general and diabetic populations. As part of the EURODIAB Prospective Complication Study, we have assessed the 7-year incidence and risk factors of prolonged QTc in people with type 1 diabetes. RESEARCH DESIGN AND METHODS: A total of 1,415 type 1 diabetic subjects, who had normal QTc at baseline, were reanalyzed after the 7-year follow-up period. QTc >0.44 s was considered abnormally prolonged. RESULTS: Cumulative incidence of prolonged QTc was 18.7%, which is twofold higher in women than in men (24.5 vs. 13.9%, P < 0.0001). At the baseline examination, incident cases were older and less physically active than nonincident cases, had higher mean values of systolic blood pressure and HDL cholesterol, and had higher frequencies of hypertension, coronary heart disease, and distal symmetrical polyneuropathy. In multivariate logistic regression analyses, female sex and higher values of A1C and systolic blood pressure were associated with the risk of prolonged QTc, whereas physical activity and BMI within the range of 21.5-23.2 kg/m2 were protective factors. In women, association with modifiable factors, particularly BMI, was stronger than in men. CONCLUSIONS: In type 1 diabetic subjects from the EURODIAB cohort, female sex, A1C, and systolic blood pressure are predictive of prolonged QTc, whereas physical activity and BMI within the range of 21.5-23.2 kg/m2 play a protective role. These findings are clinically relevant, as they may help to identify subjects at higher risk for prolonged QTc, as well as provide potential targets for risk-lowering strategies.
机译：目的：校正的QT（QTc）延长可预测普通人群和糖尿病人群的心血管死亡率。作为EURODIAB前瞻性并发症研究的一部分，我们评估了1型糖尿病患者7年时间延长QTc的发生率和危险因素。研究设计与方法：在7年的随访期后，重新分析了基线时QTc正常的1,415名1型糖尿病受试者。 QTc> 0.44 s被认为异常延长。结果：延长QTc的累积发生率为18.7％，女性比男性高出两倍（24.5比13.9％，P <0.0001）。在基线检查中，事件病例比非事件病例年龄更大，体力活动较少，收缩压和HDL胆固醇平均值更高，高血压，冠心病和远端对称性多发性神经病的发生频率更高。在多因素logistic回归分析中，女性和较高的A1C和收缩压值与QTc延长的风险相关，而体育活动和BMI在21.5-23.2 kg / m2范围内是保护因素。在女性中，与可改变因素（尤其是BMI）的关联比男性更强。结论：在EURODIAB队列的1型糖尿病患者中，女性，A1C和收缩压可预测QTc延长，而21.5-23.2 kg / m2的体力活动和BMI起保护作用。这些发现在临床上是相关的，因为它们可能有助于识别延长QTc风险的受试者，并为降低风险的策略提供潜在目标。

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