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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Targeting the telosome: therapeutic implications.
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Targeting the telosome: therapeutic implications.

机译：靶向端粒：治疗意义。

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摘要

Since telomere integrity is required to guarantee the unlimited replicative potential of cancer cells, telomerase, the enzyme responsible for telomere length maintenance in most human tumors, and lately also telomeres themselves have become extremely attractive targets for new anticancer interventions. At the current status of knowledge, it is still not possible to define the best therapeutic target between telomerase and telomeres. It is noteworthy that interfering with telomeres, through direct targeting of telomeric DNA or proteins involved in the telosome complex, could negatively affect the proliferative potential not only of tumors expressing telomerase activity but also of those that maintain their telomeres through alternative lengthening or still unknown mechanisms. This review presents the different therapeutic approaches proposed thus far and developed in preclinical tumor models and discusses the perspectives for their use in the clinical setting.
机译：由于需要端粒完整性来保证癌细胞的无限复制潜力，端粒酶是负责维持大多数人类肿瘤中端粒长度的酶，最近端粒本身也已成为新的抗癌干预措施的极具吸引力的靶标。以目前的知识水平，仍然不可能在端粒酶和端粒之间定义最佳治疗靶标。值得注意的是，通过直接靶向端粒复合体中涉及的端粒DNA或蛋白质，干扰端粒可能不仅负面影响表达端粒酶活性的肿瘤的增殖潜能，而且还会影响通过替代性延长或仍未知机制维持端粒的肿瘤的增殖潜能。 。这篇综述介绍了迄今为止提出的和在临床前肿瘤模型中发展起来的不同治疗方法，并讨论了其在临床中的应用前景。

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