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首页> 外文期刊>Diabetes care >Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH Case-Control Study.
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Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH Case-Control Study.

机译：宫内暴露于母体糖尿病和肥胖与青年2型糖尿病的关联：SEARCH病例对照研究。

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OBJECTIVE: Limited data exist on the association between in utero exposure to maternal diabetes and obesity and type 2 diabetes in diverse youth. These associations were explored in African-American, Hispanic, and non-Hispanic white youth participating in the SEARCH Case-Control Study. RESEARCH DESIGN AND METHODS: A total of 79 youth with type 2 diabetes and 190 nondiabetic control youth aged 10-22 years attended a research visit. In utero exposures to maternal diabetes and obesity were recalled by biological mothers. RESULTS: Youth with type 2 diabetes were more likely to have been exposed to maternal diabetes or obesity in utero than were nondiabetic control youth (P < 0.0001 for each). After adjusting for offspring age, sex, and race/ethnicity, exposure to maternal diabetes (odds ratio [OR] 5.7 [95% CI 2.4-13.4]) and exposure to maternal obesity (2.8 [1.5-5.2]) were independently associated with type 2 diabetes. Adjustment for other perinatal and socioeconomic factors did not alter these associations. When offspring BMI was added, the OR for the association between in utero exposure to obesity and type 2 diabetes was attenuated toward the null (OR 1.1 [0.5-2.4]). Overall, 47.2% (95% CI 30.9-63.5) of type 2 diabetes in youth could be attributed to intrauterine exposure to maternal diabetes and obesity. CONCLUSIONS: Intrauterine exposures to maternal diabetes and obesity are strongly associated with type 2 diabetes in youth. Prevention efforts may need to target, in addition to childhood obesity, the increasing number of pregnancies complicated by obesity and diabetes.
机译：目的：关于宫内暴露于母体糖尿病与肥胖和2型糖尿病的青年之间的关联的数据有限。在参加SEARCH病例对照研究的非洲裔美国人，西班牙裔和非西班牙裔白人青年中探索了这些关联。研究设计和方法：共有79名2型糖尿病青年和190名10-22岁的非糖尿病对照青年参加了研究访问。在宫内，亲生母亲回忆起母体糖尿病和肥胖症的暴露。结果：与非糖尿病对照青年相比，患有2型糖尿病的青年更有可能在子宫内暴露于母体糖尿病或肥胖症（每人P <0.0001）。在调整了后代的年龄，性别和种族/民族之后，孕产妇糖尿病的暴露（优势比[OR] 5.7 [95％CI 2.4-13.4]）和孕产妇肥胖的暴露（2.8 [1.5-5.2]）分别与2型糖尿病。其他围产期和社会经济因素的调整并没有改变这些关联。当添加后代BMI时，子宫内暴露于肥胖与2型糖尿病之间相关性的OR减弱为零（OR 1.1 [0.5-2.4]）。总体而言，青年2型糖尿病的47.2％（95％CI 30.9-63.5）可归因于宫内暴露于母体糖尿病和肥胖症。结论：宫内暴露于母体糖尿病和肥胖与青年2型糖尿病密切相关。除儿童肥胖症外，预防工作还可能需要针对因肥胖症和糖尿病而并发的妊娠增加。

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