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首页> 外文期刊>Diabetes research and clinical practice >The relationship of the peroxisome proliferator-activated receptor-gamma 2 exon 2 and exon 6 gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy.
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The relationship of the peroxisome proliferator-activated receptor-gamma 2 exon 2 and exon 6 gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy.

机译：过氧化物酶体增殖物激活受体γ2外显子2和外显子6基因多态性与土耳其2型糖尿病患者肾病和无肾病的关系。

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BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPAR gamma) has recently been shown to be associated with type 2 diabetes. We aim to investigate Turkish type 2 diabetic patients with/without diabetic nephropathy and healthy group and examined the contribution of the G/C exon 2 and T/C exon 6 of the PPAR gamma gene polymorphism to the development of diabetic nephropathy. METHODS: The PPAR gamma genotypes were determined retrospectively in 43 patients with nephropathy and 48 without nephropathy and a control group of 50 healthy individuals. Genotyping of the G/C exon 2 and T/C exon 6 of the PPAR-gamma gene polymorphism for all individuals was performed by melting curve analysis of the generated amplicons after real-time online PCR. RESULTS: This genotype (exon 2 and exon 6) distribution did not differ between control subjects and type 2 diabetic patients. The genotype frequencies and allele exon 2 were CC, 100%; GC, 0%; GG, 0% and C, 100%; G, 0% in diabetic patients with nephropathy versus CC, 97.9%; GC, 2.1%; GG, 0% and C 98.9%, G 1.1% in those without nephropathy. Genotype exon 6 frequencies in diabetic patients with nephropathy were (T/T) 0%, (T/C) 14%; (C/C) 86% versus (G/G) 0%; (G/C) 2.1%; (C/C) 97.9% in those without nephropathy. The PPAR gamma exon 2 and exon 6 genotype and allele frequencies were not different between diabetic patients with and without nephropathy. CONCLUSIONS: PPAR gamma exon 2 and exon 6 gene polymorphism is not associated with the development of diabetic nephropathy in Turkish type 2 diabetic patients.
机译：背景：过氧化物酶体增殖物激活受体γ（PPARγ）最近已显示与2型糖尿病有关。我们旨在调查土耳其2型糖尿病伴/不伴糖尿病肾病和健康人群，并研究PPARγ基因多态性的G / C外显子2和T / C外显子6对糖尿病肾病发展的贡献。方法：回顾性分析43例肾病患者和48例无肾病患者以及50例健康人的对照组中的PPARγ基因型。通过实时在线PCR后生成的扩增子的熔解曲线分析，对所有个体进行PPAR-γ基因多态性的G / C外显子2和T / C外显子6的基因分型。结果：该基因型（外显子2和外显子6）的分布在对照组和2型糖尿病患者之间没有差异。基因型频率和等位基因外显子2为CC，100％; GC，0％; GG，0％，C，100％; G，糖尿病肾病患者为0％，而CC为97.9％; GC，2.1％;在没有肾病的患者中，GG为0％，C为98.9％，G为1.1％。糖尿病肾病患者的基因型外显子6频率为（T / T）0％，（T / C）14％; （C / C）86％对（G / G）0％; （G / C）2.1％; （C / C）在没有肾病的患者中占97.9％。在有和没有肾病的糖尿病患者中，PPARγ外显子2和外显子6的基因型和等位基因频率没有差异。结论：土耳其2型糖尿病患者PPARγ外显子2和外显子6基因多态性与糖尿病肾病的发生无关。

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