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首页> 外文期刊>Diabetes research and clinical practice >Associations of coronary artery calcification and carotid intima-media thickness with plasma concentrations of vascular calcification inhibitors in type 2 diabetic patients.
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Associations of coronary artery calcification and carotid intima-media thickness with plasma concentrations of vascular calcification inhibitors in type 2 diabetic patients.

机译：2型糖尿病患者冠状动脉钙化和颈动脉内膜中层厚度与血管钙化抑制剂血浆浓度的关系。

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摘要

Vascular calcification is frequently accompanied by intima-media thickening, but the associations among these atherosclerotic features and bone-related peptides in diabetic patients are unclear. We enrolled 168 type 2 diabetic patients and 40 non-diabetic subjects consecutively admitted to our hospital. Mean intima-media thickness (mean-IMT) in common carotid arteries was measured by B-mode ultrasonography. Agatston coronary artery calcium score (CACS) was obtained using multidetector-row computed tomography (MDCT). Plasma bone-related peptides osteopontin and osteoprotegerin levels were measured. Diabetic patients had higher mean-IMT (p=0.0002) and log(CACS+1) (p<0.0001) and similar bone-related peptides compared to non-diabetic subjects. In diabetic patients classified into tertiles according to their CACS levels, those with the highest scores showed the highest mean-IMT (p=0.0004) and bone-related peptides (p<0.05) among the groups. log(CACS+1) and mean-IMT were associated (p<0.0001) and were positively correlated with osteopontin (p<0.01) and osteoprotegerin (p<0.01) in diabetic patients. Multivariate analyses revealed that the significant independent determinants of log(CACS+1) were age, duration of diabetes and osteopontin (p<0.0001) and those of mean-IMT were age, hypertension, osteopontin and osteoprotegerin (p<0.0001), respectively. We have demonstrated that vascular calcification in type 2 diabetic patients is frequently accompanied by intima-media thickening, and osteopontin may act as a vascular calcification inhibitor by increasing intima-media thickness.
机译：血管钙化常伴有内膜中层增厚，但糖尿病患者的这些动脉粥样硬化特征与骨相关肽之间的关联尚不清楚。我们招募了168名2型糖尿病患者和40名非糖尿病患者，这些患者已连续入院。普通颈动脉的平均内膜中层厚度（mean-IMT）通过B型超声检查。使用多排行计算机断层扫描（MDCT）获得Agatston冠状动脉钙化评分（CACS）。测量血浆骨相关肽骨桥蛋白和骨保护素水平。与非糖尿病患者相比，糖尿病患者的平均IMT（p = 0.0002）和log（CACS + 1）（p <0.0001）和相似的骨相关肽更高。在根据其CACS水平分类为三分位数的糖尿病患者中，得分最高的患者在各组中显示出最高的平均IMT（p = 0.0004）和骨相关肽（p <0.05）。 log（CACS + 1）和平均IMT相关（p <0.0001），并且与糖尿病患者的骨桥蛋白（p <0.01）和骨保护素（p <0.01）正相关。多变量分析显示，log（CACS + 1）的重要独立决定因素分别是年龄，糖尿病持续时间和骨桥蛋白（p <0.0001），平均IMT分别是年龄，高血压，骨桥蛋白和骨保护素（p <0.0001）。我们已经证明，2型糖尿病患者的血管钙化常伴有内膜中层增厚，而骨桥蛋白可能通过增加内膜中层厚度来充当血管钙化抑制剂。

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