Role of quantitative chest perfusion computed tomography in detecting diabetic pulmonary microangiopathy.

Kuziemski K; Pienkowska J; Slominski W; Specjalski K; Dziadziuszko K; Jassem E; Studniarek M; Kalicka R; Slominski JM

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Role of quantitative chest perfusion computed tomography in detecting diabetic pulmonary microangiopathy.

机译：定量胸部灌注计算机断层扫描在检测糖尿病性肺微血管病中的作用。

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AIMS: aim of the study was to determine the role of perfusion chest computed tomography (pCT) in evaluation of pulmonary diabetic angiopathy. METHODS: 18 never-smoking patients (10 diabetic patients and 8 healthy controls) underwent chest high resolution CT (HRCT) and then pCT scanning. In both groups, blood tests, biochemical analysis, fibrinogen, HbA(1c), spirometry, diffusion capacity for carbon monoxide (DLCO) and body pletysmography were performed.Following parameters of pulmonary perfusion have been analysed: blood volume (BV), blood flow (BF), mean transit time (MTT), time to peak (TTP) and permeability surface (PS). RESULTS: there were no statistically significant differences between groups in terms of age, sex, BMI, forced expiratory volume in one second (FEV(1)), DLCO. Chest HRCT revealed no pathologies. Significantly higher values of chest pCT for BF (p=0.05), BV (p=0.05) and PS (p=0.01) have been found in diabetics in comparison to controls. No differences were found in MTT. CONCLUSIONS: significant increase of perfusion parameters in diabetes seems to confirm pulmonary microangiopathy. The results indicate that further studies on application of pCT in diabetic patients may be beneficial for better understanding of lung microangiopathy, its diagnosing and monitoring.

机译：目的：该研究的目的是确定灌注胸部计算机断层扫描（pCT）在评估肺糖尿病性血管病中的作用。方法：18例不吸烟的患者（10例糖尿病患者和8例健康对照者）接受了胸部高分辨率CT（HRCT），然后进行了pCT扫描。两组均进行了血液检查，生化分析，纤维蛋白原，HbA（1c），肺活量测定，一氧化碳扩散能力（DLCO）和人体容积描记法。（BF），平均通过时间（MTT），到达峰时间（TTP）和渗透性表面（PS）。结果：各组之间在年龄，性别，BMI，一秒钟用力呼气量（FEV（1）），DLCO方面无统计学差异。胸部HRCT未显示任何病理。与对照组相比，糖尿病患者的胸部pCT BF（p = 0.05），BV（p = 0.05）和PS（p = 0.01）明显更高。在MTT中未发现差异。结论：糖尿病的灌注参数显着增加似乎证实了肺微血管病变。结果表明，对pCT在糖尿病患者中应用的进一步研究可能有助于更好地了解肺微血管病变，对其诊断和监测。

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《Diabetes research and clinical practice》 |2011年第1期|共7页
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Kuziemski K; Pienkowska J; Slominski W; Specjalski K; Dziadziuszko K; Jassem E; Studniarek M; Kalicka R; Slominski JM;
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1. Role of quantitative chest perfusion computed tomography in detecting diabetic pulmonary microangiopathy. [J] . Kuziemski K, Pienkowska J, Slominski W, Diabetes research and clinical practice . 2011,第1期

机译：定量胸部灌注计算机断层扫描在检测糖尿病性肺微血管病中的作用。
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3. Pulmonary artery hypertension associated with systemic scleroderma: Correlation among lung pulmonary blood volume, lung perfusion single photon emission computed tomography, and chest computed tomography images [J] . Circulation: An Official Journal of the American Heart Association . 2013,第1期

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4. Simulation of Cone Beam Computed Tomography Chest Imaging with Parallel Computing: Nodule Detectability versus Dose [C] . Shu-Ju Tu, Chris C. Shaw, Lingyun Chen Physic of Medical Imaging pt.2; Progress in Biomedical Optics and Imaging; vol.6 no.22 . 2005

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机译：慢性阻塞性肺疾病药物治疗后使用双能计算机断层扫描技术评估局部氙气通气灌注和通气-灌注不匹配的变化：视觉和定量分析
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机译：胸部高分辨率计算机断层扫描检测不定肺结节的无创表征。

Role of quantitative chest perfusion computed tomography in detecting diabetic pulmonary microangiopathy.

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