...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Diagnostic cytopathology >Cytological Features of NUT Midline Carcinoma Arising in Sino-Nasal Tract and Parotid Gland Report of Two New Cases and Review of the Literature
【24h】

Cytological Features of NUT Midline Carcinoma Arising in Sino-Nasal Tract and Parotid Gland Report of Two New Cases and Review of the Literature

机译：中鼻道和腮腺中NUT中线癌的细胞学特征2例新病例报道及文献复习

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nuclear Protein in Testis (NUT) Midline Carcinoma (NMC) represents a recently described, uncommon, high-grade and extremely lethal malignancy mainly occurring in children and young adults. Such tumors are genetically characterized by chromosomal rearrangements of the NUT gene. Cytological description of NUT carcinoma is limited and only seven cases were reported up to date. We show here another two cases studied cytologically with molecular and immunohistochemical confirmation. In both cases smears were hypercellular and composed of isolated or clustered small to medium-sized in size with roundish and oval shape cells. Nuclei were either regular or roundish containing dusty chromatin and prominent nucleoli. Mitotic figures were prominent. Cytoplasm was scant, strongly basophilic. Cell debris, necrosis, and apoptosis were also prominent. One of the cases was studied by FISH and the second case was studied by RT-PCR and BRD4-NUT translocation was found in both cases. Moreover, the clinical evolution was aggressive in both cases with rapid fatal clinical outcome. NUT carcinomas are an underdiagnosed entity which should be taken into consideration when poorly differentiated carcinomas was diagnosed in children or young adults. Cytology material may be successfully used for morphological and molecular diagnosis. (C) 2016 Wiley Periodicals, Inc.
机译：睾丸中核蛋白（NUT）中线癌（NMC）代表了一种最近描述的罕见，高度恶性和极致命的恶性肿瘤，主要发生于儿童和年轻人。这类肿瘤的遗传特征是NUT基因的染色体重排。 NUT癌的细胞学描述有限，迄今为止仅报告了7例。我们在这里显示了另外两个通过分子和免疫组织化学确认进行细胞学研究的案例。在这两种情况下，涂片都是高细胞的，由孤立的或成簇的小到中型的大小，带有圆形和椭圆形的细胞组成。细胞核呈规则或圆形，含有尘土染色质和突出的核仁。有丝分裂的数字是突出的。细胞质很少，强烈嗜碱性。细胞碎片，坏死和凋亡也很突出。其中一种情况是通过FISH研究的，另一种情况是通过RT-PCR研究的，两种情况下均发现BRD4-NUT易位。而且，在这两种情况下，临床进展都具有攻击性，并具有致命的快速临床结果。 NUT癌是诊断不足的实体，在儿童或年轻人中诊断出低分化癌时应考虑到这一点。细胞学材料可以成功地用于形态学和分子诊断。 （C）2016威利期刊公司

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号