Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.

Birch HL; Buckley GM; Davies N; Dyke HJ; Frost EJ; Gilbert PJ; Hannah DR; Haughan AF; Madigan MJ; Morgan T; Pitt WR; Ratcliffe AJ; Ray NC; Richard MD; Sharpe A; Taylor AJ; Whitworth JM; Williams SC

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Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.

机译：作为IMPDH抑制剂的新型7-甲氧基-6-恶唑-5-基-2,3-二氢-1H-喹唑啉-4-酮。

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The synthesis and biological activity of a novel series of 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones are described. Some of these compounds were found to be potent inhibitors of inosine 5'-monophosphate dehydrogenase type II (IMPDH II).

机译：描述了一系列新型的7-甲氧基-6-恶唑-5-基-2,3-二氢-1H-喹唑啉-4-酮的合成和生物活性。发现这些化合物中的一些是II型肌苷5'-单磷酸脱氢酶（IMPDH II）的有效抑制剂。

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《Bioorganic and Medicinal Chemistry Letters》 |2005年第23期|共5页
作者
Birch HL; Buckley GM; Davies N; Dyke HJ; Frost EJ; Gilbert PJ; Hannah DR; Haughan AF; Madigan MJ; Morgan T; Pitt WR; Ratcliffe AJ; Ray NC; Richard MD; Sharpe A; Taylor AJ; Whitworth JM; Williams SC;
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正文语种 eng
中图分类基础医学;
关键词
inhibitors; novel; Oxidoreductases; Inosine; 氧化还原酶类; 肌苷;

机译：inhibitors;novel;Oxidoreductases;Inosine;氧化还原酶类;肌苷;

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1. Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors. [J] . Birch HL, Buckley GM, Davies N, Bioorganic and Medicinal Chemistry Letters . 2005,第23期

机译：作为IMPDH抑制剂的新型7-甲氧基-6-恶唑-5-基-2,3-二氢-1H-喹唑啉-4-酮。
2. Identification of novel and potent isoquinoline aminooxazole-Based IMPDH inhibitors. [J] . Chen P, Norris D, Haslow KD, Bioorganic and Medicinal Chemistry Letters . 2003,第7期

机译：鉴定新型和有效的基于异喹啉氨基恶唑的IMPDH抑制剂。
3. The TosMIC approach to 3-(Oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors. [J] . Dhar TG, Shen Z, Fleener CA, Bioorganic and Medicinal Chemistry Letters . 2002,第22期

机译：3-（Oxazol-5-yl）吲哚的TosMIC方法：在基于吲哚的IMPDH抑制剂的合成中的应用。
4. IMPDH Structure and Ligand Binding [C] . Barry M. Goldstein, Dipesh Risal, Michael Strickler Symposium on Inosine Monophosphate Dehydrogenase: A Major Therapeutic Target null null . 2000

机译：IMPDH结构和配体结合
5. Synthesis of anticancer agents for inhibition of type II inosine monophosphate dehydrogenase (IMPDH). [D] . Clark, Kimberly Nicole. 2012

机译：合成用于抑制II型肌苷单磷酸脱氢酶（IMPDH）的抗癌剂。
6. Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics [O] . T-Y Wu, Y Peng, LL Pelleymounter, 2010

机译：麦考酚酸靶向肌苷单磷酸脱氢酶IMPDH1和IMPDH2的药理学研究：基因序列变异和功能基因组学
7. Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics [O] . Wu, T-Y, Peng, Y, Pelleymounter, LL, 2010

机译：麦考酚酸靶向肌苷单磷酸脱氢酶IMPDH1和IMPDH2的药理学研究：基因序列变异和功能基因组学

Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.

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