Both pain and fatigue are important possible determinants of disability in patients with the Ehlers-Danlos syndrome hypermobility type.

Voermans NC; Knoop H

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Both pain and fatigue are important possible determinants of disability in patients with the Ehlers-Danlos syndrome hypermobility type.

机译：疼痛和疲劳都是Ehlers-Danlos综合征活动过度类型患者中重要的可能的残疾决定因素。

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Patients with Ehlers-Danlos Syndrome (EDS), a group of inherited connective tissue disorders, often complain about pain. Until recently, almost no research was done on this symptom and its consequences in patients with EDS. In their interesting study, Rombaut et al. [1] showed that for patients with EDS of the hypermobility type (HT) 'moderate to severe pain is an everyday occurrence'. They also found a reduced quality of life and high level of disability in patients with EDS. The authors state that the HT probably is the most debilitating form of EDS with respect to musculoskeletal function, but as they only included HT patients a direct comparison with other subtypes with respect to the prevalence and severity of pain was not possible.

机译：Ehlers-Danlos综合征（EDS）患者是一组遗传性结缔组织疾病，经常抱怨疼痛。直到最近，几乎没有关于这种症状及其对EDS患者后果的研究。在他们有趣的研究中，Rombaut等人。 [1]表明，对于运动过度型（HT）的EDS患者，“每天都会出现中度至剧烈疼痛”。他们还发现，EDS患者的生活质量下降，残疾水平较高。作者指出，就肌肉骨骼功能而言，HT可能是最易使人衰弱的EDS形式，但由于他们仅包括HT患者，因此无法就疼痛的发生率和严重程度与其他亚型进行直接比较。

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《Disability and rehabilitation.》 |2011年第8期|共2页
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Voermans NC; Knoop H;
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1. Both pain and fatigue are important possible determinants of disability in patients with the Ehlers-Danlos syndrome hypermobility type. [J] . Voermans NC, Knoop H Disability and rehabilitation. . 2011,第8期

机译：疼痛和疲劳都是Ehlers-Danlos综合征活动过度类型患者中重要的可能的残疾决定因素。
2. Management of pain and fatigue in the joint hypermobility syndrome (a.k.a. Ehlers-Danlos syndrome, hypermobility type): Principles and proposal for a multidisciplinary approach [J] . CastoriM., MorlinoS., CellettiC., American journal of medical genetics, Part A . 2012,第8期

机译：关节过度活动综合征（又名Ehlers-Danlos综合征，运动过度型）的疼痛和疲劳处理：多学科方法的原则和建议
3. Chronic fatigue syndrome is commonly diagnosed in patients with Ehlers-Danlos syndrome hypermobility type/joint hypermobility syndrome. [J] . Castori M, Celletti C, Camerota F, Clinical and experimental rheumatology . 2011,第3期

机译：慢性疲劳综合症通常诊断为Ehlers-Danlos综合征运动过度型/关节运动过度综合症的患者。
4. Alterations in collagen structure in hypermobility and Ehlers-Danlos syndromes detected by Raman spectroscopy in vivo [C] . Carina Koch Johansson, Monika Gniadecka, Susanne Ullman, Conference on Optical Biopsy and Tissue Optics 5-6 July 2000 Amsterdam, the Netherlands . 2000

机译：拉曼光谱法在体内检测到的高运动性和Ehlers-Danlos综合征的胶原蛋白结构变化
5. The Use of Propranolol for Non-specific Beta-adrenergic Blockade to Target Gastrointestinal Manifestations and Improve Quality of Life in Hypermobile Ehlers-Danlos Syndrome Patients with Autonomic Dysfunction [D] . D'Amato, Rachel. 2020

机译：使用普萘洛尔用于非特异性β-肾上腺素能细胞，以靶向胃肠道表现，提高高毛细管ehlers-danlos综合征患者的胃肠道表现和改善自主功能障碍患者的生活质量
6. Evaluation of Kinesiophobia and Its Correlations with Pain and Fatigue in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type [O] . Claudia Celletti, Marco Castori, Giuseppe La Torre, 2006

机译：关节运动亢进综合征/ Ehlers-Danlos综合征运动过度类型的运动恐惧症及其与疼痛和疲劳的相关性评估
7. Transcriptome-Wide Expression Profiling in Skin Fibroblasts of Patients with Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type. [O] . Nicola Chiarelli, Giulia Carini, Nicoletta Zoppi, 2016

机译：联合运动过度综合征/ Ehlers-Danlos综合征患者皮肤成纤维细胞的转录组表达谱分析。

Both pain and fatigue are important possible determinants of disability in patients with the Ehlers-Danlos syndrome hypermobility type.

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