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首页> 外文期刊>Die Pharmazie >The impact of CYP3A5 on the metabolism of cyclosporine A and tacrolimus in the evaluation of efficiency and safety of immunosuppressive treatment in patients after kidney transplantation
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The impact of CYP3A5 on the metabolism of cyclosporine A and tacrolimus in the evaluation of efficiency and safety of immunosuppressive treatment in patients after kidney transplantation

机译：CYP3A5对环孢素A和他克莫司代谢的影响对肾移植术后患者免疫抑制治疗有效性和安全性的评价

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The aim of the study was to determine the impact of CYP3A5 mutation on the serum levels of immunosuppressive drugs (tacrolimus and cyclosporine A), and on the occurrence of acute rejection episodes among patients after kidney transplantation. A limited number of such research in Polish patients was also an important factor encouraging to perform the study. Fifty-two persons were recruited. The tested patients underwent kidney transplantation and were treated either with cyclosporine A (17 persons) or with tacrolimus (35 persons). The group included 21 women and 31 men. DNA was isolated from whole blood and a modified Van Schaik et al. (2002) PCR-RFLP method was used for genotyping. The serum levels were controlled at the 7th, 14th, 30th, 90th, 180th and 360th day after transplantation. The CYP3A5 genotype had no impact on the concentrations of cyclosporine A and tacrolimus at any investigated time point. No correlation between the rate of acute rejection episodes and different genotypes of the CYP3A5 isoenzyme could be proven.
机译：该研究的目的是确定CYP3A5突变对免疫抑制剂药物（他克莫司和环孢霉素A）的血清水平以及肾移植术后患者急性排斥反应发生的影响。在波兰患者中进行的此类研究数量有限，也是鼓励进行该研究的重要因素。招募了52个人。受测患者接受了肾脏移植，并接受环孢霉素A（17人）或他克莫司（35人）治疗。该组包括21名妇女和31名男子。从全血和改良的Van Schaik等人分离DNA。 （2002）PCR-RFLP方法用于基因分型。在移植后第7、14、30、90、180和360天控制血清水平。在任何调查的时间点，CYP3A5基因型对环孢霉素A和他克莫司的浓度没有影响。急性排斥反应的发生率与CYP3A5同工酶的不同基因型之间没有相关性。

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