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首页> 外文期刊>Turkish journal of biology >Anticancer activities and mechanism of action of 2 novel metal complexes, C16H34N8O5Ag2Cd and C11H16N7O2Ag3Ni
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Anticancer activities and mechanism of action of 2 novel metal complexes, C16H34N8O5Ag2Cd and C11H16N7O2Ag3Ni

机译：两种新型金属配合物C16H34N8O5Ag2Cd和C11H16N7O2Ag3Ni的抗癌活性及其作用机理

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摘要

The discovery of anticancer activity in cisplatin triggered the development of novel drugs containing metals such as platinum or ruthenium. Extremely diverse structural chemistry and the interaction of metal complexes with biomolecules resulted in the exploration of novel metal complexes with drug potential. In the present study, the anticancer and cytotoxic activities and the mechanisms of action were investigated for C16H34N8O5Ag2Cd (AN1) and C11H16N7O2Ag3Ni (AN7), 2 newly synthesized dicyanidoargentate(I) complexes. The anticancer and cytotoxic activities of AN1 and AN7 on several cancer cell lines were tested by cell proliferation and cytotoxic activity assays, respectively. The apoptotic and replication inhibitory potentials of the compounds were investigated using terminal deoxynucleotidyl transferase dUTP nick and labeling (TUNEL) and DNA topoisomerase inhibition assays. AN1 and AN7 showed significant (P < 0.05) anticancer activity and lower cytotoxicity against all cell lines tested. The TUNEL assay results indicated that AN1 and AN7 may inhibit cell proliferation by inducing apoptosis. The compounds showed very significant DNA topoisomerase I inhibitory activity. Based on the results, it is suggested that compounds AN1 and AN7 are potential anticancer drug candidates.
机译：顺铂中抗癌活性的发现引发了含有金属如铂或钌的新型药物的开发。极其多样的结构化学以及金属配合物与生物分子的相互作用导致了对具有药物潜力的新型金属配合物的探索。在本研究中，研究了C16H34N8O5Ag2Cd（AN1）和C11H16N7O2Ag3Ni（AN7）这两种新合成的双氰基银（I）配合物的抗癌和细胞毒性活性及其作用机理。分别通过细胞增殖和细胞毒性活性测定来测试AN1和AN7对几种癌细胞系的抗癌和细胞毒性活性。使用末端脱氧核苷酸转移酶dUTP缺口和标记（TUNEL）和DNA拓扑异构酶抑制试验研究了该化合物的凋亡和复制抑制潜能。 AN1和AN7对所有测试的细胞系均显示出显着的（P <0.05）抗癌活性和较低的细胞毒性。 TUNEL分析结果表明AN1和AN7可能通过诱导细胞凋亡来抑制细胞增殖。所述化合物显示出非常显着的DNA拓扑异构酶I抑制活性。根据结果​​，建议化合物AN1和AN7是潜在的抗癌药物候选物。

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