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首页> 外文期刊>Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus >Females without reflux symptoms or gastroesophageal reflux disease have less distal esophageal acid exposure than males without reflux symptoms or gastroesophageal reflux disease
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Females without reflux symptoms or gastroesophageal reflux disease have less distal esophageal acid exposure than males without reflux symptoms or gastroesophageal reflux disease

机译：没有反流症状或胃食管反流疾病的女性比没有反流症状或胃食管反流疾病的男性少食管远端酸暴露

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摘要

Ambulatory 24-hour esophageal pH monitoring is the gold standard examination to assess esophageal acid exposure. Gender-related variation is a well-recognized physiologic phenomenon in health and disease. To date, limited gender-specific 24-hour esophageal pH monitoring data are available. The aim of this study was to obtain values of esophageal pH monitoring in males and females without reflux symptoms or gastroesophageal reflux disease (GERD) to determine if gender variation exists in esophageal acid exposure among individuals without these factors. Twenty-four-hour dual esophageal pH monitoring was performed in male and female volunteers without reflux symptoms or GERD. Values for total number of reflux episodes, episodes longer than 5 minutes, total reflux time in minutes, % time with pH below 4, and longest reflux episode in the proximal/distal esophagus were obtained and recorded for both groups. The distal channel was placed 5cm and proximal channel 15cm above the manometrically determined lower esophageal sphincter. Means were compared using an independent sample t-test. Sixty-seven males and 69 females were enrolled. All subjects completed esophageal 24-hour pH monitoring without difficulty. There was no age or body mass difference between groups. Females had significantly fewer reflux episodes at both esophageal measuring sites and, significantly less total reflux time and % time with pH below 4 in the distal esophagus than males. All other parameters were similar. Significant gender-related differences exist in esophageal acid exposure, especially in the distal esophagus in individuals without reflux symptoms or GERD. These differences underscore the need for gender-specific reference values for 24-hour pH monitoring, allowing for an accurate evaluation of esophageal acid exposure in symptomatic patients.
机译：动态24小时食管pH监测是评估食管酸暴露的金标准检查。性别相关变异是健康和疾病中公认的生理现象。迄今为止，仅有有限的针对性别的24小时食管pH监测数据。这项研究的目的是获得在没有反流症状或胃食管反流病（GERD）的男性和女性中食管pH监测的价值，以确定在没有这些因素的个体中食管酸暴露中是否存在性别差异。在没有反流症状或GERD的男性和女性志愿者中进行了二十四小时的双食管pH监测。获得并记录两组的反流发作总数，超过5分钟的发作次数，以分钟计的总反流时间，pH低于4的％时间以及近端/远端食管中最长的反流发作的值。将远端通道放置在测压确定的食管下括约肌上方5cm处，将近端通道放置15cm处。使用独立样本t检验比较平均值。男性67例，女性69例。所有受试者均可轻松完成食道24小时pH监测。两组之间没有年龄或体重差异。女性在两个食道测量部位的反流事件明显少于男性，在远端食管中pH低于4的总反流时间和％时间显着少于男性。所有其他参数都相似。食管酸暴露存在明显的性别相关差异，尤其是在没有反流症状或GERD的个体中，在食管远端。这些差异凸显了24小时pH监测需要针对性别的参考值，从而可以对有症状患​​者的食道酸暴露进行准确评估。

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