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首页> 外文期刊>Developmental cell >Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle.
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Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle.

机译:外套,系绳,Rabs和SNARE共同作用以介导运输小泡的细胞内目的地。

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摘要

Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane. However, recent findings have revealed a role for the coat in directing a vesicle to its correct intracellular destination. In this review we will discuss the literature that links coat proteins to vesicle targeting events.
机译:拴系因子已显示与Rabs和SNARE和最近与外壳蛋白发生相互作用。外壳蛋白是货物选择和膜变形所必需的,以便从供体隔室中萌发出运输囊泡。曾经有人认为,囊泡必须在识别其靶膜之前脱壳。然而,最近的发现揭示了被膜在将囊泡引导至其正确的细胞内目的地中的作用。在这篇综述中,我们将讨论将外壳蛋白与囊泡靶向事件联系起来的文献。

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