Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.

ORiordan MX; Bauler LD; Scott FL; Duckett CS

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Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.

机译：真核生物进化过程中凋亡蛋白的抑制剂：主题保护模型。

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The past decade and a half has witnessed the discovery of a large, evolutionarily conserved family of cellular genes bearing homology to the prototype baculovirus Inhibitor of Apoptosis (IAP). The logical decision in the field to also refer to these cellular proteins as IAPs fails to do justice to this versatile group of factors that play a wide range of roles in eukaryotic development and homeostasis which include, but are not limited to, the regulation of programmed cell death. Here we describe the shared functional characteristics of several well-characterized IAPs whose defining motifs place them more in the category of multifunctional modular protein interaction domains.

机译：在过去的十五年中，目睹了一个与原型杆状病毒凋亡抑制剂（IAP）具有同源性的，进化上保守的细胞基因家族。在本领域中，将IAPs也称为这些细胞蛋白的逻辑决定不能使这组在真核生物发育和体内平衡中发挥广泛作用的通用因素失去公正性，这些因素包括但不限于程序性调控细胞死亡。在这里，我们描述了几个很好表征的IAP的共有功能特征，这些IAP的定义基序将它们更多地置于多功能模块化蛋白质相互作用域的范畴内。

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《Developmental cell》 |2008年第4期|共12页
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ORiordan MX; Bauler LD; Scott FL; Duckett CS;
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正文语种 eng
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1. 组蛋白去乙酰化酶抑制剂MS-275诱导骨髓瘤细胞株U266凋亡过程中Survivin的表达 [J] . 马健, 赵名, 于晓妉, 癌症（英文版） . 2009,第005期
2. Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. [J] . ORiordan MX, Bauler LD, Scott FL, Developmental cell . 2008,第4期

机译：真核生物进化过程中凋亡蛋白的抑制剂：主题保护模型。
3. 82 Pharmacokinetic–pharmacodynamic modeling of the effect of GDC-0152, a selective antagonist of the inhibitor of apoptosis (IAP) proteins, on monocyte chemotactic protein-1 (MCP-1) indicates species differences in MCP-1 response [J] . W. Fairbrother, H. Wong, N. Budha, European Journal of Cancer Supplements . 2010,第7期

机译：82凋亡抑制剂（IAP）的选择性拮抗剂GDC-0152对单核细胞趋化蛋白1（MCP-1）的作用的药代动力学-药效学模拟表明，MCP-1反应的物种差异
4. Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer [J] . ZhangT., LiY., ZouP., Biopharmaceutics and Drug Disposition . 2013,第6期

机译：在人乳腺癌小鼠异种移植模型中多种凋亡蛋白抑制剂（IAPs）拮抗剂（SM-406 / AT-406）的生理基础药代动力学和药效学建模
5. Degraded collagen fragments activate NF-kB and protect human smooth muscle cells against apoptosis through induction of inhibitor of apoptosis proteins (lAPs) [C] . K. von Wnuck Lipinski, N. Ferri, B. Levka Nordrhein-Westfa?lische Akademie der Wissenschaften . 2005

机译：降解的胶原片段激活NF-KB并通过诱导凋亡蛋白抑制剂（圈）保护人平滑肌细胞免受细胞凋亡
6. Role and regulation of X -linked inhibitor of apoptosis protein expression during development of the rat ovarian follicle in vitro. [D] . Wang, Yifang. 2003

机译：X连锁凋亡抑制蛋白表达在体外大鼠卵泡发育过程中的作用和调控。
7. INHIBITOR OF APOPTOSIS (IAP) PROTEINS IN EUKARYOTIC EVOLUTION AND DEVELOPMENT: A MODEL OF THEMATIC CONSERVATION [O] . Mary X.D. ORiordan, Laura D. Bauler, Fiona L. Scott, -1

机译：真核生物进化和发展中的凋亡抑制蛋白（IAP）：主题保护模型
8. Inhibitor of Apoptosis Proteins in Eukaryotic Evolution and Development: A Model of Thematic Conservation [O] . ORiordan Mary X.D., Bauler Laura D., Scott Fiona L., 2008

机译：凋亡蛋白在真核生物进化和发展中的抑制剂：主题保护的模型。

Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.

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