...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Developmental cell >Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst
【24h】

Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst

机译：Notch和Hippo在Cdx2上收敛以指定小鼠胚泡中的滋养层谱系

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The first lineage choice in mammalian embryogenesis is that between the trophectoderm, which gives rise to the trophoblast of the placenta, and the inner cell mass, from which is derived the embryo proper and the yolk sac. The establishment of these lineages is preceded by the inside-versus-outside positioning of cells in the early embryo and stochastic expression of key transcription factors, which is then resolved into lineage-restricted expression. The regulatory inputs that drive this restriction and how they relate to cell position are largely unknown. Here, we show an unsuspected role of Notch signaling in regulating trophectoderm-specific expression of Cdx2 in cooperation with TEAD4. Notch activity is restricted to outer cells and is able to influence positional allocation of blastomeres, mediating preferential localization to the trophectoderm. Our results show that multiple signaling inputs at preimplantation stages specify the first embryonic lineages.
机译：哺乳动物胚胎发生的第一个谱系选择是滋养外胚层和胎盘内胚层之间，胎盘胚层产生胎盘的滋养层，而胎盘内层则衍生出固有的胚胎和卵黄囊。在建立这些谱系之前，先将细胞在早期胚胎中由内而外定位，然后随机表达关键转录因子，然后再将其解析为谱系限制性表达。导致这种限制以及它们如何与细胞位置相关的法规输入在很大程度上尚不清楚。在这里，我们展示了Notch信号与TEAD4协同调节Cdx2的滋养外胚层特异性表达的意想不到的作用。刻槽活动仅限于外部细胞，并能够影响卵裂球的位置分配，介导优先定位于滋养外胚层。我们的结果表明，在植入前的多个信号输入指定了第一个胚胎谱系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号