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首页> 外文期刊>Digestive Diseases and Sciences >The effects of a fat- and sugar-enriched diet and chronic stress on nonalcoholic fatty liver disease in male Wistar rats.
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The effects of a fat- and sugar-enriched diet and chronic stress on nonalcoholic fatty liver disease in male Wistar rats.

机译：富含脂肪和糖的饮食和慢性应激对雄性Wistar大鼠非酒精性脂肪肝的影响。

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PURPOSE: The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is still under debate. The aim of this study was to investigate the effects of a long-term fat- and sugar-enriched diet (FSED) and chronic stress (CS) on NAFLD. METHODS: Male Wistar rats were fed on either a standard diet or a FSED and given CS, a random electric foot shock (2 hr/morning and afternoon per day), or not for 12 weeks. After the experimental period, epididymal adipose tissue weight, sign of visceral obesity (VO), and hepatic index (HI) were measured. At sacrifice blood samples and liver were obtained. Histology of the liver was blindly determined by a pathologist. RESULTS: Histopathologically, moderate to severe steatosis, ballooning hepatocytes, and portal or lobules inflammation were observed in the FSED+CS group. However, mild to moderate steatosis with a few portal inflammation in the FSED group and mild steatosis or not with a few portal inflammation in the CS group were found correspondingly. In addition, more severe blood-fat disorder, high HI, fatty metabolic dysfunction, oxidative stress, high expressions of C-reactive protein mRNA and low expressions of peroxisome proliferator-activated receptor alpha mRNA in the liver were also revealed in the FSED+CS group. But, the degree of VO was not different between the FSED and FSED+CS groups. CONCLUSION: The observations strongly suggest that chronic stress can aggravate fat- and sugar-enriched diet-induced NAFLD from steatosis to steatohepatitis in male Wistar rats, although VO is not changed.
机译：目的：非酒精性脂肪性肝病（NAFLD）的发病机理仍在争论中。这项研究的目的是研究长期富含脂肪和糖的饮食（FSED）和慢性应激（CS）对NAFLD的影响。方法：雄性Wistar大鼠以标准饮食或FSED喂养，并给予CS，随机电击（每天2小时/早晨和每天下午）或不连续12周。实验期过后，测量附睾脂肪组织重量，内脏肥胖的体征（VO）和肝指数（HI）。处死时获得血液样品和肝脏。肝脏的组织学由病理学家盲目确定。结果：FSED + CS组观察到组织病理学，中度至重度脂肪变性，肝细胞膨胀，门静脉或小叶炎症。然而，在FSED组中，轻度至中度脂肪变性伴有少量门静脉炎症;而在CS组中，轻度至中度脂肪变性伴有少量门静脉炎症。此外，在FSED + CS中还发现肝脏中存在更严重的血脂异常，高HI，脂肪代谢功能障碍，氧化应激，C反应蛋白mRNA高表达和过氧化物酶体增殖物激活受体αmRNA低表达。组。但是，FSED组和FSED + CS组之间的VO程度没有差异。结论：观察结果强烈表明，慢性应激可以使雄性Wistar大鼠从脂肪变性到脂肪性肝炎加重饮食中脂肪和糖分丰富的NAFLD，尽管VO并没有改变。

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