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首页> 外文期刊>Digestive Diseases and Sciences >Influence of E. coli strain Nissle 1917 (EcN) on intestinal gas dynamics and abdominal sensation.
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Influence of E. coli strain Nissle 1917 (EcN) on intestinal gas dynamics and abdominal sensation.

机译：大肠杆菌菌株Nissle 1917（EcN）对肠道气体动力学和腹部感觉的影响。

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E. coli strain Nissle 1917 (EcN) is a probiotic clinically used with various indications. However, especially at the beginning of treatment, some patients report abdominal bloating. In a prospective, randomized, double-blind study in 30 healthy individuals we assessed the influences of EcN on intestinal gas dynamics and abdominal sensation. After one week without medication volunteers orally received 2.5-25 x 10(9) colony-forming units of EcN or placebo per day for 21 days. EcN was well tolerated and did not significantly affect abdominal symptoms, stool frequency or stool consistency. During gas challenge at different days no difference in the perception scores (range from 0 = no perception to 6 = pain) was observed between the two groups: the mean perception score was 1.2 (SD 0.2) in the EcN group and 1.4 (SD 0.2) in the placebo group. EcN had no relevant influence on intestinal gas dynamics.
机译：大肠杆菌Nissle 1917菌株（EcN）是临床上用于各种适应症的益生菌。但是，特别是在治疗开始时，一些患者报告腹部胀气。在一项针对30位健康个体的前瞻性，随机，双盲研究中，我们评估了EcN对肠内气体动力学和腹部感觉的影响。一星期不使用药物后，志愿者每天口服2.5-25 x 10（9）个EcN菌落形成单位或安慰剂，共21天。 EcN的耐受性良好，对腹部症状，大便次数或大便稠度没有明显影响。在不同天数的气体挑战期间，两组之间的知觉得分没有差异（从0 =无知觉到6 =疼痛）：EcN组的平均知觉得分为1.2（标准差0.2）和1.4（标准差0.2） ）在安慰剂组中。 EcN对肠道气体动力学没有相关影响。

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