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首页> 外文期刊>Digestive Diseases and Sciences >A feasibility study of probiotics pretreatment as a bowel preparation for colonoscopy in constipated patients.
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A feasibility study of probiotics pretreatment as a bowel preparation for colonoscopy in constipated patients.

机译：益生菌预处理作为便秘患者肠镜检查肠道准备的可行性研究。

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BACKGROUND: The use of probiotics to treat constipation is based on the premise that supplying the gut with healthy bacteria in the form of probiotics can help normalize intestinal function. The aim of this study was to determine the efficacy of a 2-week probiotics pretreatment with oral sodium phosphate (NaP) for bowel cleansing before colonoscopy in patients with constipation. METHODS: Patients with constipation were prospectively randomized to receive a 2-week probiotics course comprising a mixture of Bacillus subtilis and Streptococcus faecium (group A, n = 51) or placebo (group B, n = 53) with an oral NaP solution. During the same period, another 107 patients with normal bowel movement were enrolled and received the probiotics treatment (n = 53, group C) or placebo (n = 54, group D). The primary outcome measure was the quality of bowel cleansing. Postendoscopic symptoms were estimated using a visual analogue scale. RESULTS: Patients having normal defecation presented with better bowel preparation than those with constipation (57.9% versus 37.5%; P = 0.003). Probiotics pretreatment (group A) was more effective at bowel cleansing for colonoscopy compared with placebo (group B) in constipated patients (54.9% versus 20.8%; P < 0.001). In contrast, preparation quality did not differ significantly between groups C and D. Preparation-related adverse events and postendoscopic symptoms were more frequent and severe in group B than in group A. CONCLUSION: Two weeks of probiotics pretreatment as part of bowel preparation significantly improves colonic mucosa visualization during colonoscopy and reduces preparation-related and postendoscopic gastrointestinal symptoms in constipated patients.
机译：背景：使用益生菌治疗便秘的前提是，以益生菌形式向肠道供应健康细菌可以帮助肠道功能正常化。这项研究的目的是确定在便秘患者进行结肠镜检查之前用口服磷酸钠（NaP）进行为期2周的益生菌预处理以清洁肠道的功效。方法：对便秘患者进行前瞻性随机化，接受2周益生菌疗程，包括枯草芽孢杆菌和粪便链球菌（A组，n = 51）或安慰剂（B组，n = 53）与口服NaP溶液的混合物。在同一时期，另外107名肠蠕动正常的患者入组并接受了益生菌治疗（n = 53，C组）或安慰剂（n = 54，D组）。主要结果指标是肠清洁的质量。使用视觉模拟量表评估内镜后症状。结果：排便正常的患者比便秘的患者肠道准备更好（57.9％比37.5％; P = 0.003）。在便秘患者中，益生菌预处理（A组）对结肠镜检查的肠道清洁效果比安慰剂（B组）更高（54.9％对20.8％; P <0.001）。相比之下，C组和D组之间的制剂质量没有显着差异。与A组相比，B组中与制剂相关的不良事件和内镜后症状更为频繁和严重。结论：肠道准备的益生菌预处理两周显着改善结肠镜检查过程中的结肠粘膜可视化可减少便秘患者与制剂相关的症状和内镜后胃肠道症状。

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