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首页> 外文期刊>Digestive Diseases and Sciences >Over-expression of EphA2 and EphrinA-1 in human gastric adenocarcinoma and its prognostic value for postoperative patients.
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Over-expression of EphA2 and EphrinA-1 in human gastric adenocarcinoma and its prognostic value for postoperative patients.

机译：EphA2和EphrinA-1在人胃腺癌中的过度表达及其对术后患者的预后价值。

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摘要

This study aims to investigate the expression and significance of EphA2 and EphrinA-1 in human gastric adenocarcinoma progression and prognosis. The expression of EphA2 and EphrinA-1 was detected in the cell lines and tissues of gastric adenocarcinoma. Different expression levels of EphA2 and EphrinA-1 were found in two cell lines. The expression of EphA2 and EphrinA-1 was significantly higher in gastric adenocarcinoma tissues than in normal tissues. Statistical analysis showed a significant correlation of EphA2 expression with the depth of tumor invasion, tumor-node-metastasis (TNM) stages, and lymph node metastasis. EphrinA-1 over-expression was significantly correlated with TNM stages and lymph node metastasis, while EphA2 expression was found to be an independent prognostic factor of postoperative gastric adenocarcinoma. In conclusion, the increased expression of EphA2 and EphrinA-1 plays an important role in the progression of human gastric adenocarcinoma, in which elevated EphA2 expression is an independent factor that indicates poor prognosis in postoperative gastric adenocarcinoma.
机译：本研究旨在探讨EphA2和EphrinA-1在人胃腺癌进展和预后中的表达及其意义。在胃腺癌的细胞系和组织中检测到EphA2和EphrinA-1的表达。在两种细胞系中发现了EphA2和EphrinA-1的不同表达水平。胃腺癌组织中EphA2和EphrinA-1的表达明显高于正常组织。统计分析表明EphA2表达与肿瘤浸润深度，肿瘤淋巴结转移（TNM）分期和淋巴结转移密切相关。 EphrinA-1的过表达与TNM分期和淋巴结转移密切相关，而EphA2的表达是术后胃腺癌的独立预后因素。总之，EphA2和EphrinA-1的表达增加在人胃腺癌的发展中起着重要作用，其中EphA2的表达升高是表明术后胃腺癌预后不良的独立因素。

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