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首页> 外文期刊>Digestive Diseases and Sciences >Comparative evaluation of different doses of green tea extract alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats.
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Comparative evaluation of different doses of green tea extract alone and in combination with sulfasalazine in experimentally induced inflammatory bowel disease in rats.

机译：比较不同剂量的绿茶提取物单独或与柳氮磺吡啶合用对大鼠实验性炎症性肠病的比较评估。

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BACKGROUND: The exact etiopathology of inflammatory bowel disease is still unclear. Most of the therapies present are directed towards symptomatic improvement. Surgical therapy in the form of restorative proctocolectomy is reserved for the terminal stage disease, which is unresponsive to medical therapy. The present study was conducted to evaluate the effect of green tea in experimentally induced inflammatory bowel disease. METHODS: A total of 36 animals were included in the study. The animals were divided into five groups (n = 6): Group I-Vehicle (ethanol), group II-TNBS + ethanol, group III-green tea-treated group was divided into two sub-groups on the basis of different doses: group IIIA-TNBS + green tea (35 mg/kg), group IIIB-TNBS + green tea (70 mg/kg), group IV-TNBS + sulfasalazine (360 mg/kg), group V-TNBS + sulfasalazine (360 mg/kg) + green tea (least effective dose found in group III). After completion of 2 weeks of treatment, the rats were killed under ether anesthesia by cervical dislocation for assessment of intestinal inflammation, histological analysis, myeloperoxidase assay, malondialdehyde assay, and TNF-alpha estimation. RESULTS: The study showed that green tea alone and in combination with sulfasalazine reduced inflammatory changes induced by tri nitro benzene sulfonic acid in rats. This reduction is associated with reduced malondialdehyde, lipid peroxidation, and TNF-alpha. This correlates well with both gross morphological and histopathological scores. CONCLUSIONS: The authors concluded that a combination of green tea extract with sulfasalazine showed greater efficacy than single drug treatment.
机译：背景：炎性肠病的确切病因仍不清楚。目前的大多数疗法都针对症状改善。修复性直肠结肠切除术形式的外科治疗被保留用于对药物治疗无反应的晚期疾病。本研究旨在评估绿茶在实验性炎症性肠病中的作用。方法：总共36只动物被纳入研究。将动物分为五组（n = 6）：第一组车辆（乙醇），第二组TNBS +乙醇，第三组绿茶治疗组根据不同剂量分为两个亚组： IIIA-TNBS组+绿茶（35 mg / kg），IIIB-TNBS组+绿茶（70 mg / kg），IV-TNBS组+柳氮磺吡啶（360 mg / kg），V-TNBS +柳氮磺吡啶（360 mg） / kg）+绿茶（第三组中发现的最低有效剂量）。在完成2周的治疗后，以乙醚麻醉的方式通过颈脱位法处死大鼠，以评估肠道炎症，组织学分析，髓过氧化物酶测定，丙二醛测定和TNF-α估计。结果：研究表明，单独绿茶以及与柳氮磺胺吡啶合用，可减轻三硝基苯磺酸引起的炎症变化。这种减少与丙二醛减少，脂质过氧化和TNF-α相关。这与总体形态学和组织病理学评分都很好地相关。结论：作者得出的结论是，绿茶提取物与柳氮磺胺吡啶的组合显示出比单药治疗更高的功效。

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