Omeprazole inhibits natural killer cell functions.

Alkim H; Unal S; Okur H; Imir T

首页> 外文期刊>Digestive Diseases and Sciences >Omeprazole inhibits natural killer cell functions.

【24h】

Omeprazole inhibits natural killer cell functions.

机译：奥美拉唑抑制自然杀伤细胞功能。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

This study was designed to determine the possible effects of omeprazole on human natural killer cells. Peripheral venous blood samples were taken from 20 peptic ulcer patients before and at the 14th and the 28th days of omeprazole treatment. Mononuclear cells were removed from blood and their capability of making conjugation with K562 target cells and lysing K562 target cells was evaluated. A significant decrease was found (P < 0.001) in the 14th and the 28th days compared with the basal value of the capability of the mononuclear cells to conjugate with the K562 target cells and to lyse them. This study demonstrated that omeprazole significantly reduces natural killer cell functions. This finding suggests that omeprazole may also have some effects on the other systems in addition to parietal cell acid secretion.

机译：这项研究旨在确定奥美拉唑对人类自然杀伤细胞的可能作用。在奥美拉唑治疗的第14天和第28天以及治疗的第14天和第28天，从20名消化性溃疡患者中采集外周静脉血样本。从血液中去除单核细胞，并评价其与K562靶细胞结合和裂解K562靶细胞的能力。与单核细胞与K562靶细胞结合并裂解它们的能力的基础值相比，在第14天和第28天发现了显着降低（P <0.001）。这项研究表明奥美拉唑显着降低了自然杀伤细胞的功能。这一发现表明，奥美拉唑除了顶细胞酸分泌外，对其他系统也可能有一些影响。

著录项

来源
《Digestive Diseases and Sciences》 |2008年第2期|共5页
作者
Alkim H; Unal S; Okur H; Imir T;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
Adult; Anti-Ulcer Agents; Cytotoxicity Tests; Immunologic; Female; Humans; 成年人; 抗溃疡病药; 细胞毒性试验; 免疫; 杀伤细胞; 天然; 奥美拉唑; 壁细胞; 胃;

机译：Adult;Anti-Ulcer Agents;Cytotoxicity Tests;Immunologic;Female;Humans;成年人;抗溃疡病药;细胞毒性试验;免疫;杀伤细胞;天然;奥美拉唑;壁细胞;胃;

相似文献

外文文献
中文文献
专利

1. Omeprazole inhibits natural killer cell functions. [J] . Alkim H, Unal S, Okur H, Digestive Diseases and Sciences . 2008,第2期

机译：奥美拉唑抑制自然杀伤细胞功能。
2. Reply to the letter to the editor 'Epstein-Barr virus reactivation in extranodal natural killer/T-cell lymphoma patients: a previously unrecognized serious adverse event in a pilot study with romidepsin, histone deacetylase (HDAC) inhibitors when combined with a proteasome inhibitor are safe and effective in patients with extranodal natural killer/T-cell lymphoma' by Tan et al. [J] . Kim S. J., Kim W. S. Annals of oncology: official journal of the European Society for Medical Oncology . 2016,第11期

机译：回复给编辑的信'结外自然杀手/ T细胞淋巴瘤患者中的爱泼斯坦-巴尔病毒再激活：罗米地辛，组蛋白脱乙酰酶（HDAC）抑制剂与蛋白酶体抑制剂联合使用时，在一项先导研究中以前未认识到的严重不良事件是Tan等人对结外自然杀手/ T细胞淋巴瘤患者安全有效。
3. The physiological activation and inhibition features of immunity cell functions. Receptor structures and intracellular signal ways of macrophages and natural killer cells [J] . Khaitov RM, Manko VM Российский　физиологический　журнал . 2006,第6期

机译：免疫细胞功能的生理激活和抑制特征。巨噬细胞和自然杀伤细胞的受体结构和细胞内信号途径
4. Unnatural killer cells: TRAIL-coated leukocytes that kill cancer cells in the circulation [C] . Mitchell M.J., Wayne E.C., Rana K., 2014 40th Annual Northeast Bioengineering Conference . 2014

机译：非自然杀伤细胞：TRAIL涂层的白细胞可杀死循环中的癌细胞
5. Novel Roles for the Transcriptional Repressor PRDM1 in Human Natural Killer Cells and Identification of an Inhibitor of its Interacting Methyltransferase G9a. [D] . Smith, Matthew Adams. 2011

机译：转录阻遏物PRDM1在人类自然杀伤细胞中的新作用及其相互作用的甲基转移酶G9a抑制剂的鉴定。
6. Human Uterine Natural Killer Cells but Not Blood Natural Killer Cells Inhibit Human Immunodeficiency Virus Type 1 Infection by Secretion of CXCL12 [O] . Teddy F. Mselle, Alexandra L. Howell, Mimi Ghosh, 2009

机译：人子宫自然杀伤细胞但不包括血液自然杀伤细胞通过分泌CXCL12抑制人免疫缺陷病毒1型感染
7. Monkeypox virus infection of rhesus macaques induces massive expansion of natural killer cells but suppresses natural killer cell functions. [O] . Haifeng Song, Nicole Josleyn, Krisztina Janosko, 2013

机译：恒河猴的猴痘病毒感染诱导自然杀伤细胞的大量扩增，但抑制自然杀伤细胞功能。

Omeprazole inhibits natural killer cell functions.

摘要

著录项

相似文献

相关主题

期刊订阅