...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Digestive Diseases and Sciences >Pharmacological basis for the medicinal use of psyllium husk (Ispaghula) in constipation and diarrhea.
【24h】

Pharmacological basis for the medicinal use of psyllium husk (Ispaghula) in constipation and diarrhea.

机译：洋车前子皮（Ispaghula）用于便秘和腹泻的药理基础。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The objective of this study was to determine the pharmacological basis of the medicinal use of psyllium husk (Ispaghula) in gastrointestinal motility disorders. METHODS: In-vivo studies were conducted on mice, and isolated rabbit jejunum and guinea-pig ileum were used in in-vitro experiments. RESULTS: The crude extract of Ispaghula (Po.Cr) had a laxative effect in mice at 100 and 300 mg/kg, which was partially sensitive to atropine or SB203186 (5-HT(4) antagonist). At higher doses (500 and 1,000 mg/kg), Po.Cr had antisecretory and antidiarrheal activity. In guinea-pig ileum, Po.Cr (1-10 mg/ml) had a stimulatory effect, which was partially sensitive to atropine or SB203186. In rabbit jejunum, Po.Cr had a partially atropine-sensitive stimulatory effect followed by relaxation at 10 mg/ml. The relaxation was inhibited by the presence of L-NAME, a nitric oxide (NO) synthase inhibitor, or methylene blue, a guanylyl cyclase inhibitor. Similarly, the relaxant effect of Po.Cr on K(+) (80 mM)-induced contractions, was attenuated in the presence of L-NAME or methylene blue. Activity-directed fractionation of Po.Cr revealed that the gut stimulatory and inhibitory constituents were widely distributed in the aqueous and organic fractions. CONCLUSION: This study demonstrates that Ispaghula has a gut-stimulatory effect, mediated partially by muscarinic and 5-HT(4) receptor activation, which may complement the laxative effect of its fiber content, and a gut-inhibitory activity possibly mediated by blockade of Ca(2+) channels and activation of NO-cyclic guanosine monophosphate pathways. This may explain its medicinal use in diarrhea. It is, perhaps, also intended by nature to offset an excessive stimulant effect.
机译：背景：这项研究的目的是确定药用的车前子壳（Ispaghula）在胃肠动力性疾病中的药理基础。方法：对小鼠进行体内研究，并将离体的兔空肠和豚鼠回肠用于体外实验。结果：Ispaghula（Po.Cr）的粗提取物对小鼠的泻药作用为100和300 mg / kg，对阿托品或SB203186（5-HT（4）拮抗剂）部分敏感。在较高剂量（500和1,000 mg / kg）下，Po.Cr具有抗分泌和止泻活性。在豚鼠回肠中，Po.Cr（1-10 mg / ml）有刺激作用，对阿托品或SB203186部分敏感。在兔空肠中，Po.Cr具有部分对阿托品敏感的刺激作用，随后以10 mg / ml的速度松弛。通过一氧化氮（NO）合酶抑制剂L-NAME或鸟苷酸环化酶抑制剂亚甲基蓝的存在抑制松弛。同样，在L-NAME或亚甲基蓝的存在下，Po.Cr对K（+）（80 mM）诱导的收缩的松弛作用减弱。 Po.Cr的活性导向分馏显示，肠刺激和抑制成分广泛分布在水性和有机级分中。结论：这项研究表明，Ispaghula具有肠刺激作用，部分由毒蕈碱和5-HT（4）受体激活介导，这可能补充其纤维含量的通便作用，并且可能通过阻断肠粘膜而介导肠抑制活性。 Ca（2+）通道和NO环鸟苷单磷酸途径的激活。这可以解释其在腹泻中的药用。从本质上讲，也许也旨在抵消过度的刺激作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号