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首页> 外文期刊>Drug development and industrial pharmacy >Hydrogel-gauze dressing for moderate-to-severe atopic dermatitis: development and efficacy study on atopic dermatitis-like skin lesions in NC/Nga mice
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Hydrogel-gauze dressing for moderate-to-severe atopic dermatitis: development and efficacy study on atopic dermatitis-like skin lesions in NC/Nga mice

机译：水凝胶纱布敷料治疗中度至重度特应性皮炎：NC / Nga小鼠特应性皮炎样皮肤病变的发展和功效研究

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摘要

Topical emollients are known to provide symptomatic relief for atopic dermatitis. In hospitals, wet-wrap therapy has been shown to benefit children with moderate-to-severe atopic dermatitis (AD), but the application of wet-wraps is tedious and time-consuming. Topical emollients have low residence time and often dry out easily. The aim of this work was to develop a hydrogel-gauze dressing that is not only easy to apply but also rehydrates and traps moisture to provide longer relief for AD patients. In this study, a prototype hydrogel-gauze dressing was developed with varying ratios of sodium carboxymethylcellulose (NaCMC) and propylene glycol. The hydrogel-gauze dressings were assessed based on the moisture vapor transmission rate, moisture absorption, mechanical properties and storage stability over three months. Then, the efficacy of the hydrogel-gauze dressing was compared to topical emollients using transgenic NC/Nga mice with AD-like lesions. The NaCMC hydrogel-gauze dressings significantly lowered transepidermal water loss, and the animals displayed a faster recovery, which indicates that hydrogel-gauze dressings can trap moisture more effectively and accelerate AD healing. Hence, we propose that hydrogel-gauze dressings can potentially become an alternative to wet-wrap therapy due to the ease of application and the higher efficacy compared to topical products.
机译：已知外用润肤剂可减轻特应性皮炎的症状。在医院中，湿敷疗法已显示出对患有中度至重度特应性皮炎（AD）的儿童有益，但是湿敷疗法的应用乏味且耗时。外用润肤剂的滞留时间短，并且经常容易变干。这项工作的目的是开发一种水凝胶纱布敷料，该敷料不仅易于使用，而且还能补水和捕获水分，从而为AD患者提供更长的缓解时间。在这项研究中，开发了具有不同比例的羧甲基纤维素钠（NaCMC）和丙二醇的水凝胶纱布敷料原型。基于三个月内的水蒸气透过率，水分吸收，机械性能和储存稳定性评估了水凝胶纱布敷料。然后，使用具有AD样病变的转基因NC / Nga小鼠将水凝胶纱布敷料的功效与局部润肤剂进行比较。 NaCMC水凝胶纱布敷料可显着降低经表皮水分流失，并且动物恢复速度更快，这表明水凝胶纱布敷料可更有效地捕获水分并加速AD愈合。因此，我们建议水凝胶纱布敷料有可能成为湿包裹疗法的替代品，这是因为与局部产品相比，其易于使用和更高的功效。

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