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首页> 外文期刊>Drug discovery today >Harnessing bioinformatics to discover new vaccines.
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Harnessing bioinformatics to discover new vaccines.

机译:利用生物信息学发现新疫苗。

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摘要

Vaccine design is highly suited to the application of in silico techniques, for both the discovery and development of new and existing vaccines. Here, we discuss computational contributions to epitope mapping and reverse vaccinology, two techniques central to the new discipline of immunomics. Also discussed are methods to improve the efficiency of vaccination, such as codon optimization and adjuvant discovery in addition to the identification of allergenic proteins. We also review current software developed to facilitate vaccine design.
机译:疫苗设计非常适合计算机模拟技术的应用,用于发现和开发新疫苗和现有疫苗。在这里,我们讨论了对表位作图和反向疫苗学的计算贡献,这是免疫学新学科的两项核心技术。还讨论了除鉴定变应原蛋白外,还提高疫苗接种效率的方法,例如密码子优化和佐剂发现。我们还将审查为方便疫苗设计而开发的当前软件。

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