Integration of fragment screening and library design.

Siegal G; Ab E; Schultz J

首页> 外文期刊>Drug discovery today >Integration of fragment screening and library design.

【24h】

Integration of fragment screening and library design.

机译：片段筛选和文库设计的集成。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

With more than 10 years of practical experience and theoretical analysis, fragment-based drug discovery (FBDD) has entered the mainstream of the pharmaceutical and biotech industries. An array of biophysical techniques has been used to detect the weak interaction between a fragment and the target. Each technique presents its own requirements regarding the fragment collection and the target; therefore, in order to optimize the potential of FBDD, the nature of the target should be a driving factor for simultaneous development of both the library and the screening technology. A roadmap is now available to guide fragment-to-lead evolution when structural information is available. The next challenge is to apply FBDD to targets for which high-resolution structural information is not available.

机译：基于片段的药物发现（FBDD）拥有10多年的实践经验和理论分析，已进入制药和生物技术行业的主流。已经使用了一系列生物物理技术来检测片段与靶标之间的弱相互作用。每种技术都对片段收集和目标提出了自己的要求。因此，为了优化FBDD的潜力，目标的性质应该是同时开发文库和筛选技术的驱动因素。现在，在可获得结构信息时，可以使用路线图来指导片段到铅的进化。下一个挑战是将FBDD应用于无法获得高分辨率结构信息的目标。

著录项

来源
《Drug discovery today》 |2007年第24期|共8页
作者
Siegal G; Ab E; Schultz J;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Aspects of disease screening; Libraries; drug discovery; experience; development aspects; 图书馆;

机译：疾病筛查方面;图书馆;药物发现;经验;发展方面;图书馆;

相似文献

外文文献
中文文献
专利

1. Integration of fragment screening and library design. [J] . Siegal G, Ab E, Schultz J Drug discovery today . 2007,第23a24期

机译：片段筛选和文库设计的集成。
2. Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design. [J] . Rhodes DI, Peat TS, Vandegraaff N, Antiviral chemistry & chemotherapy . 2011,第4期

机译：通过片段筛选和基于结构的设计确定了抑制HIV-1整合酶的新机制的结构基础。
3. Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design. [J] . Rhodes DI, Peat TS, Vandegraaff N, Antiviral chemistry & chemotherapy . 2011,第4期

机译：基于碎片筛选和基于结构的设计鉴定的HIV-1整合酶的新机制的结构基础。
4. High Throughput Cytotoxicity Screening of Anti-HER2 Immunotoxins Conjugated with Antibody Fragments from Phage-Displayed Synthetic Antibody Libraries [C] . Hong-Sen Chen, Shin-Chen Hou, Hung-Wei Lin, PEGS . 2016

机译：与噬菌体展示合成抗体文库的抗体片段缀合的抗HER2免疫毒素的高通量细胞毒性筛选
5. Fragment-based library screening and structure-based optimization of selective inhibitors for protozoan diseases [D] . Shibata, Sayaka 2011

机译：基于片段的文库筛选和基于结构的原生动物疾病选择性抑制剂优化
6. Structures of endothiapepsin–fragment complexes from crystallographic fragment screening using a novel diverse and affordable 96-compound fragment library [O] . Franziska U. Huschmann, Janina Linnik, Karine Sparta, 2016

机译：使用新颖多样且可负担得起的96化合物片段库通过晶体学片段筛选筛选内皮抑素-片段复合物的结构
7. Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library [O] . Huschmann, Franziska U, Linnik, Janina, Sparta, Karine, 2016

机译：使用新颖，多样且价格合理的96-化合物片段文库，从结晶片段筛选中得到内皮肽酶 - 片段复合物的结构

Integration of fragment screening and library design.

摘要

著录项

相似文献

相关主题

期刊订阅