Pharmacogenetics of EGFR and VEGF inhibition.

Pander J; Gelderblom H; Guchelaar HJ

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Pharmacogenetics of EGFR and VEGF inhibition.

机译：EGFR和VEGF抑制的药物遗传学。

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Even though treatment of several types of solid tumours has improved in the past few years with the introduction of the monoclonal antibodies against epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF), response rates to these targeted therapies are modest. Pharmacogenetic factors have the potential to select patients with higher chance of response to agents that target these pathways. This review provides an overview over germ-line variations in genes that are potentially involved in the pharmacodynamics of the monoclonal antibodies cetuximab, panitumumab and bevacizumab, and which may underlie variable anti-tumour response.

机译：尽管通过引入针对表皮生长因子受体（EGFR）和血管内皮生长因子（VEGF）的单克隆抗体，在过去几年中对几种类型的实体瘤的治疗已有所改善，但对这些靶向疗法的反应率却不高。药物遗传因素有可能选择对靶向这些途径的药物有较高反应机会的患者。这篇综述概述了可能与单克隆抗体西妥昔单抗，帕尼单抗和贝伐单抗的药效学有关的基因的种系变异，并可能是可变的抗肿瘤反应的基础。

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《Drug discovery today》 |2007年第24期|共7页
作者
Pander J; Gelderblom H; Guchelaar HJ;
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正文语种 eng
中图分类药学;
关键词
bevacizumab; c-erbB-1 Proto-Oncogenes; Pharmacogenetics; Psychological inhibition; 遗传药理学; 抗体; 单克隆;

机译：bevacizumab;c-erbB-1 Proto-Oncogenes;Pharmacogenetics;Psychological inhibition;遗传药理学;抗体;单克隆;

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1. Pharmacogenetics of EGFR and VEGF inhibition. [J] . Pander J, Gelderblom H, Guchelaar HJ Drug discovery today . 2007,第23a24期

机译：EGFR和VEGF抑制的药物遗传学。
2. Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. [J] . Marwick JA, Stevenson CS, Giddings J, American Journal of Physiology . 2006,第5期

机译：香烟烟雾破坏大鼠肺部和COPD患者的VEGF165-VEGFR-2受体信号转导复合物：VEGFR-2抑制的形态学影响。
3. Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. [J] . Marwick JA, Stevenson CS, Giddings J, American Journal of Physiology . 2006,第5期

机译：香烟烟雾破坏大鼠肺部和COPD患者的VEGF165-VEGFR-2受体信号转导复合物：VEGFR-2抑制的形态学影响。
4. Determination of EGFR and VEGF signaling pathway activity by immuno-MALDI to predict the outcome of targeted colorectal cancer (CRC) treatment [C] . Robert Popp, Andrew G. Chambers, Adriana Aguilar-Mahecha, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：免疫马尔迪的EGFR和VEGF信号通路活性预测靶向结直肠癌（CRC）治疗的结果
5. The regulation of growth factor receptors EGFR and IGF-IR and the growth factor VEGF by thioredoxin-1. [D] . Bair, Warner B., III. 2006

机译：硫氧还蛋白-1对生长因子受体EGFR和IGF-1R和生长因子VEGF的调节。
6. VEGF-A VEGF-C VEGF-R2 EGFR and HER2 in serum plus EGFR in tissue of patients with triple-negative breast cancer [O] . R Iosifidou, G Galaktidou, A Ananiadis, 2009

机译：三阴性乳腺癌患者血清中的VEGF-AVEGF-CVEGF-R2EGFR和HER2以及组织中的EGFR
7. MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition. [O] . Elena Ortiz-Zapater, Richard W Lee, William Owen, 2017

机译：肺腺癌中的mET-EGFR二聚化依赖于EGFR突变并且被mET激酶抑制改变。

Pharmacogenetics of EGFR and VEGF inhibition.

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