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首页> 外文期刊>Dose-response >CONCENTRATION-DEPENDENT EFFECTS OF RHODIOLA ROSEA ON LONG-TERM SURVIVAL AND STRESS RESISTANCE OF YEAST SACCHAROMYCES CEREVISIAE: THE INVOLVEMENT OF YAP 1 AND MSN2/4 REGULATORY PROTEINS
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CONCENTRATION-DEPENDENT EFFECTS OF RHODIOLA ROSEA ON LONG-TERM SURVIVAL AND STRESS RESISTANCE OF YEAST SACCHAROMYCES CEREVISIAE: THE INVOLVEMENT OF YAP 1 AND MSN2/4 REGULATORY PROTEINS

机译：玫瑰红景天浓度对酵母菌长期存活和抗逆性的影响：YAP 1和MSN2 / 4调控蛋白的参与

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摘要

Concentration-dependent effects of aqueous extract from R. rosea root on long-term survival and stress resistance of budding yeast Saccharomyces cerevisiae were studied. At low concentrations, R. rosea aqueous extract extended yeast chronological lifespan, enhanced oxidative stress resistance of stationary-phase cells and resistance to number stressors in exponentially growing cultures. At high concentrations, R. rosea extract sensitized yeast cells to stresses and shortened yeast lifespan. These biphasic concentration-responses describe a common hormetic phenomenon characterized by a low-dose stimulation and a high-dose inhibition. Yeast pretreatment with low doses of R. rosea extract enhanced yeast survival and prevented protein oxidation under H2O2-induced oxidative stress. Positive effect of R. rosea extract on yeast survival under heat shock exposure was not accompanied with changes in antioxidant enzyme activities and levels of oxidized proteins. The deficiency in transcriptional regulators, Msn2/Msn4 and Yap1, abolished the positive effect of low doses of R. rosea extract on yeast viability under stress challenges. Potential involvement of Msn2/Msn4 and Yap1 regulatory proteins in realization of R. rosea beneficial effects is discussed.
机译：研究了玫瑰蔷薇根水提物对出芽酵母酿酒酵母的长期存活和抗逆性的浓度依赖性作用。在低浓度下，玫瑰蔷薇水提取物延长了酵母的时间寿命，增强了固定相细胞的氧化应激抗性，并在指数生长的培养物中对数量胁迫产生了抗性。在高浓度下，玫瑰蔷薇提取物使酵母细胞对压力敏感并缩短了酵母的寿命。这些双相浓度反应描述了一种常见的恋物癖现象，其特征在于低剂量刺激和高剂量抑制。用低剂量的玫瑰蔷薇提取物进行酵母预处理可提高酵母的存活率，并防止H2O2诱导的氧化应激下蛋白质的氧化。罗莎红景天提取物对热休克条件下酵母存活的积极影响并不伴随着抗氧化酶活性和氧化蛋白水平的变化。转录调节因子Msn2 / Msn4和Yap1的缺乏，消除了低剂量玫瑰花提取物对应激挑战下酵母活力的积极影响。讨论了Msn2 / Msn4和Yap1调节蛋白在实现玫瑰蔷薇有益效果中的潜在作用。

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