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首页> 外文期刊>Drug discovery today >Metabolic modeling: a tool of drug discovery in the post-genomic era.
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Metabolic modeling: a tool of drug discovery in the post-genomic era.

机译:代谢建模:后基因组时代的药物发现工具。

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摘要

The Human Genome Project, DNA microarrays, proteome chips and metabolic profiles, among others, are generating unprecedented amounts of valuable information about the genetic and metabolic responses of organisms to stimuli. This wealth of information poses a great scientific challenge, namely the development of novel, effective methods for functional analysis and interpretation. It is proposed here that biomathematical systems models must accompany data generation and management. A particularly effective framework for this purpose is canonical modeling based on Biochemical Systems Theory. The key concept of this theory is the formulation of biological phenomena as systems of differential equations, in which all processes are represented as products of power-law functions.
机译:人类基因组计划,DNA芯片,蛋白质组芯片和代谢谱等正在产生有关生物对刺激的遗传和代谢反应的前所未有的有价值的信息。如此丰富的信息构成了巨大的科学挑战,即开发新颖,有效的功能分析和解释方法。在此建议生物数学系统模型必须伴随数据生成和管理。为此目的,一个特别有效的框架是基于生化系统理论的规范建模。该理论的关键概念是将生物现象表述为微分方程组,其中所有过程都表示为幂律函数的乘积。

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