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Myostatin: More than just a regulator of muscle mass

机译:肌生长抑制素:不仅仅是调节肌肉质量

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摘要

The presence of sufficient skeletal muscle mass is of paramount importance for body function and the myostatin cascade is known to inhibit muscle growth in mammals. In addition, myostatin seems to have an important role in the cross-talk between skeletal muscle and adipose tissue and is involved in insulin sensitivity. In this article we highlight the latest developments related to the myostatin system, emphasizing therapeutic implications for wasting diseases and also the involvement of the system in other organs, in addition to skeletal muscle, such as heart or adipose tissue. Moreover, we highlight the possible role of the myostatin system in the cross-talk between skeletal muscle and adipose tissue, an important aspect that deserves consideration in wasting diseases.
机译:足够的骨骼肌质量的存在对于机体功能至关重要,而肌肉生长抑制素级联反应可抑制哺乳动物的肌肉生长。另外,肌生长抑制素似乎在骨骼肌与脂肪组织之间的串扰中具有重要作用,并且与胰岛素敏感性有关。在本文中,我们强调与氯化筒箭毒碱系统的最新进展,强调治疗意义的消耗性疾病,也是系统的其他器官的参与,除了骨骼肌,如心脏或脂肪组织。此外,我们强调了肌肉生长抑制素系统在骨骼肌与脂肪组织之间的串扰中的可能作用,这在浪费疾病方面值得考虑。

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